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Articles Published Processes
12/7/2018 3:57:11 AM | Browse: 980 | Download: 1978
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Received |
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2018-09-05 02:34 |
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Peer-Review Started |
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2018-09-05 05:50 |
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To Make the First Decision |
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2018-10-24 01:47 |
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Return for Revision |
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2018-10-24 07:53 |
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Revised |
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2018-11-12 23:48 |
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Second Decision |
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2018-11-13 08:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-11-13 21:50 |
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Articles in Press |
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2018-11-13 21:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-11-19 00:09 |
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Typeset the Manuscript |
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2018-12-06 03:26 |
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Publish the Manuscript Online |
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2018-12-07 03:57 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Glucocorticoid receptor regulates expression of microRNA-22 and downstream signaling pathway in apoptosis of pancreatic acinar cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qiang Fu, Chuan-Jiang Liu, Xu Zhang, Zhen-Sheng Zhai, Yu-Zhu Wang, Ming-Xing Hu, Xian-Ling Xu, Hong-Wei Zhang and Tao Qin |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
31671440 |
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| Corresponding Author |
Tao Qin, MD, PhD, Doctor, Doctor, Professor, Department of Hepato-Biliary-Pancreatic Surgery, Henan Provincial People’s Hospital（People's Hospital of Zhengzhou University）, School of Medicine, Zhengzhou University, No.7 Weiwu Road, Zhengzhou 450003, Henan Province, China. goodfreecn@163.com |
| Key Words |
MicroRNA-22; Apoptosis; Pancreatic acinar cells; Erb-b2 receptor tyrosine kinase 3; Glucocorticoid receptor |
| Core Tip |
The severity of acute pancreatitis (AP) is inversely related to the rate of apoptosis of pancreatic acinar cells. MicroRNA-22 (miR-22) might promote caerulein-induced apoptosis of pancreatic acinar cells (AR42J) via down-regulating the expression of its target gene, Erb-b2 receptor tyrosine kinase 3 (ErbB3) and the PI3k/Akt signaling pathway. Glucocorticoid receptor transcriptionally repressed the expression of miR-22 by binding to the miR-22 promoter transcription start site. The upregulation of miR-22 expression resulting from silencing Nr3c1 contributed to the apoptosis of AR42J cells. |
| Publish Date |
2018-12-07 03:57 |
| Citation |
Fu Q, Liu CJ, Zhang X, Zhai ZS, Wang YZ, Hu MX, Xu XL, Zhang HW, Qin T. Glucocorticoid receptor regulates expression of microRNA-22 and downstream signaling pathway in apoptosis of pancreatic acinar cells. World J Gastroenterol 2018; 24(45): 5120-5130 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i45/5120.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i45.5120 |
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