| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Relationship between response to lusutrombopag and splenic volume
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Haruki Uojima, Yoshitaka Arase, Norio Itokawa, Masanori Atsukawa, Takashi Satoh, Koji Miyazaki, Hisashi Hidaka, Ji Hyun Sung, Makoto Kako, Kota Tsuruya, Tatehiro Kagawa, Katsuhiko Iwakiri, Ryouichi Horie and Wasaburo Koizumi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Haruki Uojima, MD, Doctor, Doctor, Department of Gastroenterology, Internal Medicine, Shonankamakura General Hospital, Kitasato University School of Medicine, 1370-1 Okamoto, Kamakura, Kanagawa 247-8533, Japan. kiruha@kitasato-u.ac.jp |
| Key Words |
Lusutrombopag; Portal hypertension; Splenic volume; Thrombocytopenia; Thrombopoietin receptor agonist |
| Core Tip |
Lusutrombopag is an oral, small-molecule thrombopoietin receptor agonist used for the treatment of thrombocytopenic patients with chronic liver diseases. However, the response to this drug is unpredictable. The study aimed to assess the correlation between the clinical characteristics of patients with chronic liver disease and the efficacy of lusutrombopag treatment. Splenic volume influences the change in platelet counts after administration of lusutrombopag in patients with chronic liver disease. Splenic volume increase is negatively related to changes in the platelet count. |
| Publish Date |
2018-12-13 06:32 |
| Citation |
Uojima H, Arase Y, Itokawa N, Atsukawa M, Satoh T, Miyazaki K, Hidaka H, Sung JH, Kako M, Tsuruya K, Kagawa T, Iwakiri K, Horie R, Koizumi W. Relationship between response to lusutrombopag and splenic volume. World J Gastroenterol 2018; 24(46): 5271-5279 |
| URL |
https://www.wjgnet.com/1007-9327/full/v24/i46/5271.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v24.i46.5271 |
