| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qi-Xiong Qin, Xue-Min Cheng, Li-Zhi Lu, Yun-Fei Wei, Da-Cheng Wang, Hai-Hua Li, Guo-Hui Li, Hong-Bin Liang, Sheng-Yu Li, Li Chen and Zhi-Jian Liang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81260186 |
| Guangxi Natural Science Foundation |
2015GXNSFAA139228 |
| Guangxi Natural Science Foundation |
2016GXNSFAA380281 |
| Guangxi Medical and Health and Appropriate Technology Development and Promotion Application Project |
S201660 |
| Innovation Project of Guangxi Graduate Education |
YCSW2018105 |
| National Key Research and Development Programme |
2018YFC1311300 |
|
| Corresponding Author |
Zhi-Jian Liang, MD, PhD, Professor, Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, No. 22 Shuangyong Road, Nanning 530021, Guangxi Province, China. lzj200415@126.com |
| Key Words |
Colorectal cancer; Ischemic stroke; Biomarker; Pathogenesis |
| Core Tip |
Although cancer-related stroke has long been known, its biomarkers and underling pathogenesis are still unclear. It was hypothesized that a specific cancer type may affect the development of ischemic stroke (IS) according to its primary site, pathological type, and growth stage. It is reported that colorectal cancer can increase the risk of IS. We conducted a retrospective study on colorectal cancer-related IS (CRCIS) patients. We suggest that hypercoagulability induced by elevated carcinoembryonic antigen and increased neutrophil count are the main pathogenic factors in CRCIS, and the CRCIS Index, which serves as a biomarker of CRCIS, needs further study. |
| Publish Date |
2018-11-21 04:08 |
| Citation |
Qin QX, Cheng XM, Lu LZ, Wei YF, Wang DC, Li HH, Li GH, Liang HB, Li SY, Chen L, Liang ZJ. Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke. World J Gastroenterol 2018; 24(43): 4950-4958 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i43/4950.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i43.4950 |
