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Articles Published Processes
6/25/2019 9:17:49 AM | Browse: 730 | Download: 1422
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Received |
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2018-09-07 01:35 |
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Peer-Review Started |
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2018-09-07 04:49 |
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To Make the First Decision |
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2018-11-29 07:43 |
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Return for Revision |
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2018-12-17 07:14 |
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Revised |
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2019-03-14 09:13 |
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Second Decision |
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2019-03-22 01:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-03-28 04:40 |
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Articles in Press |
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2019-03-28 04:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-06-25 05:05 |
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Publish the Manuscript Online |
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2019-06-25 09:17 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Leptin-induced Notch and IL-1 signaling crosstalk in endometrial adenocarcinoma is associated with invasiveness and chemoresistance
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Danielle Daley-Brown, Adriana Harbuzariu, Ann Anu Kurian, Gabriela Oprea-Ilies and Ruben Rene Gonzalez-Perez |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The National Institute of Health |
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| Corresponding Author |
Ruben Rene Gonzalez-Perez, PhD, Full Professor, Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, United States. rgonzalez@msm.edu |
| Key Words |
Endometrial cancer; Leptin; Notch; Interleukin-1; Notch, IL-1 and Leptin crosstalk outcome; Chemoresistance |
| Core Tip |
It’s the first time we report that leptin induces Notch expression in endometrial cancer (EmCa) cells. Moreover, leptin induction of NILCO molecules was higher in type II EmCa cells that showed increased aggressiveness and resistance to Paclitaxel’s cytotoxic effects. Remarkably, the use of a leptin inhibitor, IONP-LPrA2, re-sensitizes EmCa cells to Paclitaxel that suggests targeting NILCO could be a new strategy to increase chemotherapeutic efficiency in type II EmCa that lacks targeted therapies. |
| Publish Date |
2019-06-25 09:17 |
| Citation |
Daley-Brown D, Harbuzariu A, Kurian AA, Opre-Ilies G, Gonzalez-Perez. Leptin-induced Notch and IL-1 signaling crosstalk in endometrial adenocarcinoma is associated with invasiveness and chemoresistance. World J Clin Oncol 2019; 10(6): 222-233 |
| URL |
https://www.wjgnet.com/2218-4333/full/v10/i6/222.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v10.i6.222 |
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