Publication Name	World Journal of Gastroenterology
Manuscript ID	4220
Country	Italy

Received	2013-06-21 10:07
Peer-Review Started	2013-06-21 15:39
To Make the First Decision	2013-07-19 08:57
Return for Revision	2013-07-20 23:02
Revised	2013-07-24 23:18
Second Decision	2013-08-20 12:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-20 13:47
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-08-22 22:59
Typeset the Manuscript	2013-10-13 16:58
Publish the Manuscript Online	2013-11-08 14:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Gastroesophageal reflux disease: Update on inflammation and symptom perception
Manuscript Source	Invited Manuscript
All Author List	Annamaria Altomare, Michele Pier Luca Guarino, Silvia Cocca, Sara Emerenziani and Michele Cicala
Funding Agency and Grant Number
Corresponding Author	Michele Cicala, MD, PhD, Unit of Digestive Disease, Campus Bio Medico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy. m.cicala@unicampus.it
Key Words	Gastroesophageal reflux disease; Mucosal inflammation; Heartburn; Esophagitis; Hypersensitivity
Core Tip	The present study aimed to explore the mechanisms involved in the pathogenesis of gastroesophageal reflux disease (GERD) symptoms and complications, which remain to be fully elucidated. Despite recent evidence confirming the important production of inflammatory mediators and neurotransmitters in the pathogenesis of GERD, the interplay between esophageal inflammation and hypersensitivity is not clear. Based on the literature and on personal experimental studies, this paper attempts to summarize the evidence concerning the inflammatory pathway involved in GERD pathogenesis, to better define the possible distinction between erosive and non-erosive reflux disease patients and to provide new therapeutic approaches.
Publish Date	2013-11-08 14:06
Citation	Altomare A, Guarino MPL, Cocca S, Emerenziani S, Cicala M. Gastroesophageal reflux disease: Update on inflammation and symptom perception. World J Gastroenterol 2013; 19(39): 6523-6528
URL	http://www.wjgnet.com/1007-9327/full/v19/i39/6523.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i39.6523

Full Article (PDF)	WJG-19-6523.pdf
Manuscript File	4220-Review.docx
Answering Reviewers	4220-Answering reviewers.pdf
Copyright License Agreement	4220-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4220-Language certificate.pdf
Peer-review Report	4220-Peer review(s).pdf
Scientific Editor Work List	4220-Scientific editor work list.doc