Publication Name	World Journal of Gastroenterology
Manuscript ID	42516
Country	Japan

Received	2018-10-02 09:00
Peer-Review Started	2018-10-02 12:59
First Decision by Editorial Office Director	2018-11-01 03:15
Return for Revision	2018-11-01 09:16
Revised	2018-11-07 03:16
Publication Fee Transferred
Second Decision by Editor	2018-11-16 07:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2018-11-16 18:43
Articles in Press	2018-11-16 18:43
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-12-26 02:54
Publish the Manuscript Online	2018-12-27 08:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Near-infrared photoimmunotherapy of pancreatic cancer using an indocyanine green-labeled anti-tissue factor antibody
Manuscript Source	Unsolicited Manuscript
All Author List	Winn Aung, Atsushi B Tsuji, Aya Sugyo, Hiroki Takashima, Masahiro Yasunaga, Yasuhiro Matsumura and Tatsuya Higashi
ORCID	Author(s) ORCID Number Winn Aung http://orcid.org/0000-0002-0896-7158 Atsushi B Tsuji http://orcid.org/0000-0003-2726-288X Aya Sugyo http://orcid.org/0000-0002-5174-4478 Hiroki Takashima http://orcid.org/0000-0001-6487-7344 Masahiro Yasunaga http://orcid.org/0000-0002-5712-9847 Yasuhiro Matsumura http://orcid.org/0000-0003-4331-8177 Tatsuya Higashi http://orcid.org/0000-0002-8338-4737
Funding Agency and Grant Number	Funding Agency Grant Number Supported by (partially) a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan, to Aung W 17K10460
Corresponding Author	Winn Aung, MBBS, PhD, Senior Researcher, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. winn.aung@qst.go.jp
Key Words	Pancreatic cancer; Anti-tissue factor antibody; Indocyanine green; Photoimmunotherapy; Near-infrared
Core Tip	We examined whether anti-tissue factor (TF) antibody 1849-indocyanine green (ICG) conjugate (1849-ICG) induced the photoimmunotherapeutic effect in a pancreatic cancer xenograft. There was no report about employing 1849-ICG conjugate which selectively binds the target antigen TF for near-infrared photoimmunotherapy (NIR-PIT) of tumor, though some studies have suggested the usefulness of anti-TF 1849 in cancer imaging and therapy. Our study proposes for the first time that 1849-ICG conjugate is a desirable candidate for new treat­ment modality NIR-PIT of pancreatic cancer after evalua­ting its cytotoxic and antitumor effects via in vitro and in vivo studies in mouse model of pancreatic cancer.
Publish Date	2018-12-27 08:56
Citation	Aung W, Tsuji AB, Sugyo A, Takashima H, Yasunaga M, Matsumura Y, Higashi T. Near-infrared photoimmunotherapy of pancreatic cancer using an indocyanine green-labeled anti-tissue factor antibody. World J Gastroenterol 2018; 24(48): 5491-5504
URL	https://www.wjgnet.com/1007-9327/full/v24/i48/5491.htm
DOI	https://dx.doi.org/10.3748/wjg.v24.i48.5491

Full Article (PDF)	WJG-24-5491.pdf
Full Article (Word)	WJG-24-5491.docx
The ARRIVE Guidelines	42516-The ARRIVE guidelines.pdf
Manuscript File	42516-Review.docx
Answering Reviewers	42516-Answering reviewers.pdf
Audio Core Tip	42516-Audio core tip.mp3
Biostatistics Review Certificate	42516-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	42516-Conflict-of-interest statement.pdf
Copyright License Agreement	42516-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	42516-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	42516-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	42516-Language certificate.pdf
Supplementary Material	42516-Supplementary-Material-revision.pdf
Peer-review Report	42516-Peer-review(s).pdf
Scientific Misconduct Check	42516-Scientific misconduct check.pdf
Scientific Editor Work List	42516-Scientific editor work list.pdf