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12/27/2018 8:56:32 AM | Browse: 229 | Download: 146
Publication Name World Journal of Gastroenterology
Manuscript ID 42516
Country/Territory Japan
2018-10-02 09:00
Peer-Review Started
2018-10-02 12:59
To Make the First Decision
2018-11-01 06:56
Return for Revision
2018-11-01 09:16
2018-11-07 03:16
Second Decision
2018-11-16 07:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-16 18:43
Articles in Press
2018-11-16 18:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-12-26 02:54
Publish the Manuscript Online
2018-12-27 08:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Near-infrared photoimmunotherapy of pancreatic cancer using an indocyanine green-labeled anti-tissue factor antibody
Manuscript Source Unsolicited Manuscript
All Author List Winn Aung, Atsushi B Tsuji, Aya Sugyo, Hiroki Takashima, Masahiro Yasunaga, Yasuhiro Matsumura and Tatsuya Higashi
Author(s) ORCID Number
Winn Aung http://orcid.org/0000-0002-0896-7158
Atsushi B Tsuji http://orcid.org/0000-0003-2726-288X
Aya Sugyo http://orcid.org/0000-0002-5174-4478
Hiroki Takashima http://orcid.org/0000-0001-6487-7344
Masahiro Yasunaga http://orcid.org/0000-0002-5712-9847
Yasuhiro Matsumura http://orcid.org/0000-0003-4331-8177
Tatsuya Higashi http://orcid.org/0000-0002-8338-4737
Funding Agency and Grant Number
Funding Agency Grant Number
Supported by (partially) a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan, to Aung W 17K10460
Corresponding author Winn Aung, MBBS, PhD, Senior Researcher, Senior Researcher, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. winn.aung@qst.go.jp
Keywords Pancreatic cancer; Anti-tissue factor antibody; Indocyanine green; Photoimmunotherapy; Near-infrared
Core Tip We examined whether anti-tissue factor (TF) antibody 1849-indocyanine green (ICG) conjugate (1849-ICG) induced the photoimmunotherapeutic effect in a pancreatic cancer xenograft. There was no report about employing 1849-ICG conjugate which selectively binds the target antigen TF for near-infrared photoimmunotherapy (NIR-PIT) of tumor, though some studies have suggested the usefulness of anti-TF 1849 in cancer imaging and therapy. Our study proposes for the first time that 1849-ICG conjugate is a desirable candidate for new treat­ment modality NIR-PIT of pancreatic cancer after evalua­ting its cytotoxic and antitumor effects via in vitro and in vivo studies in mouse model of pancreatic cancer.
Publish Date 2018-12-27 08:56
Citation Aung W, Tsuji AB, Sugyo A, Takashima H, Yasunaga M, Matsumura Y, Higashi T. Near-infrared photoimmunotherapy of pancreatic cancer using an indocyanine green-labeled anti-tissue factor antibody. World J Gastroenterol 2018; 24(48): 5491-5504
Url https://www.wjgnet.com/1007-9327/full/v24/i48/5491.htm
DOI https://dx.doi.org/10.3748/wjg.v24.i48.5491
Full Article (PDF) WJG-24-5491.pdf
Full Article (Word) WJG-24-5491.docx
Manuscript File 42516-Review.docx
Answering Reviewers 42516-Answering reviewers.pdf
Audio Core Tip 42516-Audio core tip.mp3
Biostatistics Review Certificate 42516-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42516-Conflict-of-interest statement.pdf
Copyright License Agreement 42516-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42516-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 42516-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 42516-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 42516-Language certificate.pdf
Supplementary Material 42516-Supplementary-Material-revision.pdf
Peer-review Report 42516-Peer-review(s).pdf
Scientific Misconduct Check 42516-Scientific misconduct check.pdf
Scientific Editor Work List 42516-Scientific editor work list.pdf