Publication Name	World Journal of Gastroenterology
Manuscript ID	42571
Country	Greece

Received	2018-09-28 01:51
Peer-Review Started	2018-09-28 09:07
To Make the First Decision	2018-10-17 01:03
Return for Revision	2018-10-23 02:06
Revised	2018-10-27 11:38
Second Decision	2018-11-07 09:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-11-08 02:24
Articles in Press	2018-11-08 02:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-12-26 02:42
Publish the Manuscript Online	2018-12-27 08:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Role of cenicriviroc in the management of nonalcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Georgios Neokosmidis and Konstantinos Tziomalos
ORCID	Author(s) ORCID Number Georgios Neokosmidis http://orcid.org/0000-0003-1858-9098 Konstantinos Tziomalos http://orcid.org/0000-0002-3172-1594
Funding Agency and Grant Number
Corresponding Author	Konstantinos Tziomalos, MD, MSc, PhD, Assistant Professor, First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, 1 Stilponos Kyriakidi Street, Thessaloniki 54636, Greece. ktziomal@auth.gr
Key Words	Cenicriviroc; Macrophages; Nonalcoholic fatty liver disease; Fibrosis; Nonalcoholic steatohepatitis
Core Tip	Macrophages appear to play an important role in the development and progression of hepatic fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Accordingly, modulation of macrophage trafficking might represent an attractive therapeutic strategy in this popu­lation. Cenicriviroc is an oral inhibitor of the chemokine ligand 2/C-C chemokine receptor 2 pathway, which plays an important role in the hepatic recruitment of the macrophages. Preclinical studies and a phase 2b study in humans suggest that this agent might hold promise in the management of NAFLD.
Publish Date	2018-12-27 08:56
Citation	Neokosmidis G, Tziomalos K. Role of cenicriviroc in the management of nonalcoholic fatty liver disease. World J Gastroenterol 2018; 24(48): 5415-5417
URL	https://www.wjgnet.com/1007-9327/full/v24/i48/5415.htm
DOI	https://dx.doi.org/10.3748/wjg.v24.i48.5415

Full Article (PDF)	WJG-24-5415.pdf
Full Article (Word)	WJG-24-5415.docx
Manuscript File	42571-Review.docx
Answering Reviewers	42571-Answering reviewers.pdf
Audio Core Tip	42571-Audio core tip.wma
Conflict-of-Interest Disclosure Form	42571-Conflict-of-interest statement.pdf
Copyright License Agreement	42571-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	42571-Non-Native Speakers of English Editing Certificate.docx
Peer-review Report	42571-Peer-review(s).pdf
Scientific Misconduct Check	42571-Scientific misconduct check.pdf
Scientific Editor Work List	42571-Scientific editor work list.pdf