Publication Name	World Journal of Hepatology
Manuscript ID	42636
Country	China

Received	2018-10-05 02:39
Peer-Review Started	2018-10-06 00:14
To Make the First Decision	2018-11-16 01:43
Return for Revision	2018-11-21 03:07
Revised	2018-11-24 03:54
Second Decision	2018-12-03 00:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-12-05 05:56
Articles in Press	2018-12-05 05:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-02-24 06:13
Publish the Manuscript Online	2019-02-26 11:29

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Colorectal liver metastases: An update on multidisciplinary approach
Manuscript Source	Invited Manuscript
All Author List	Felix Che-Lok Chow and Kenneth Siu-Ho Chok
ORCID	Author(s) ORCID Number Felix Che-Lok Chow http://orcid.org/0000-0001-8800-9525 Kenneth Siu-Ho Chok http://orcid.org/0000-0001-7921-3807
Funding Agency and Grant Number
Corresponding Author	Kenneth Siu-Ho Chok, FRCS (Ed), Associate Professor, Department of Surgery and State Key Laboratory for Liver Research, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong , China. chok6275@hku.hk
Key Words	Colorectal cancer; Liver metastases; Hepatic resection; Neoadjuvant therapy; Adjuvant chemotherapy; Intra-arterial therapy; Precision medicine; Multidisciplinary approach
Core Tip	Surgery offers the only hope of cure in colorectal liver metastasis. It can be performed if complete metastasectomy is attainable. There is no consensus on the ideal management strategy for synchronous disease. A subset of patients presenting with unresectable disease may become eligible for resection after liver remnant augmentation or conversion therapy (chemo-therapeutics +/- biological agents). Amid increasing application of loco-regional therapies to colorectal liver metastasis, their role in the treatment paradigm remains to be defined. Refined patient selection – with greater emphasis on tumour biology – is essential to improving treatment outcome. The multidisciplinary approach helps determine the optimal treatment strategy from an expanding armamentarium of therapeutic options for each patient.
Publish Date	2019-02-26 11:29
Citation	Chow FCL, Chok KSH. Colorectal liver metastases: An update on multidisciplinary approach. World J Hepatol 2019; 11(2): 150-172
URL	https://www.wjgnet.com/1948-5182/full/v11/i2/150.htm
DOI	https://dx.doi.org/10.4254/wjh.v11.i2.150

Full Article (PDF)	WJH-11-150.pdf
Full Article (Word)	WJH-11-150.docx
Manuscript File	42636-Review.docx
Answering Reviewers	42636-Answering reviewers.pdf
Audio Core Tip	42636-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	42636-Conflict-of-interest statement.pdf
Copyright License Agreement	42636-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	42636-Non-Native Speakers of English Editing Certificate.pdf
Peer-review Report	42636-Peer-review(s).pdf
Scientific Misconduct Check	42636-Scientific misconduct check.pdf
Scientific Editor Work List	42636-Scientific editor work list.pdf