Publication Name	World Journal of Cardiology
Manuscript ID	4266
Country	Greece

Received	2013-06-24 10:25
Peer-Review Started	2013-06-24 12:30
To Make the First Decision	2013-07-19 08:58
Return for Revision	2013-07-20 23:05
Revised	2013-07-30 03:43
Second Decision	2013-08-16 19:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-08-17 00:46
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-29 17:44
Publish the Manuscript Online	2013-09-26 16:28

ISSN	1949-8462 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Hyponatremia in patients with heart failure
Manuscript Source	Invited Manuscript
All Author List	Theodosios D Filippatos and Moses S Elisaf
Funding Agency and Grant Number
Corresponding Author	Moses S Elisaf, MD, FRSH, FASA, FISA, Professor, Department of Internal Medicine, School of Medicine, University of Ioannina, Staurou Niarchou Avenue, 45110 Ioannina, Greece. egepi@cc.uoi.gr
Key Words	Heart failure; Hyponatremia; Sodium; Vasopressin; Vasopressin-receptor antagonists; Tolvaptan; Conivaptan; Lixivaptan
Core Tip	Patients with heart failure and hyponatremia have increased morbidity and mortality compared with subjects with normal sodium levels. Established treatment options for hyponatremia in heart failure such as fluid restriction or the use of hypertonic saline with loop diuretics have limited efficacy and compliance issues. Arginine vasopressin (AVP)-receptor antagonists increase sodium levels and exhibit beneficial effects on hemodynamic variables in patients with heart failure. However, double-blind, placebo-controlled trials examining the effects of AVP-receptor antagonists on mortality, quality of life and length of hospital stay in patients with heart failure and hyponatremia are missing.
Publish Date	2013-09-26 16:28
Citation	Filippatos TD, Elisaf MS. Hyponatremia in patients with heart failure. World J Cardiol 2013; 5(9): 317-328
URL	http://www.wjgnet.com/1949-8462/full/v5/i9/317.htm
DOI	http://dx.doi.org/10.4330/wjc.v5.i9.317

Full Article (PDF)	WJC-5-317.pdf
Manuscript File	4266-Review.docx
Answering Reviewers	4266-Answering reviewers.pdf
Copyright License Agreement	4266-Copyright assignment.doc
Peer-review Report	4266-Peer review(s).pdf
Scientific Editor Work List	4266-Scientific editor work list.doc