Publication Name	World Journal of Gastroenterology
Manuscript ID	4278
Country	Japan

Received	2013-06-25 09:33
Peer-Review Started	2013-06-25 14:20
To Make the First Decision	2013-07-05 18:37
Return for Revision	2013-07-17 17:53
Revised	2013-08-02 19:25
Second Decision	2013-09-16 17:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 06:16
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-24 16:23
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Branched-chain amino acids in liver diseases
Manuscript Source	Invited Manuscript
All Author List	Kazuto Tajiri and Yukihiro Shimizu
Funding Agency and Grant Number
Corresponding Author	Yukihiro Shimizu, MD, PhD, Gastroenterology Unit, Nanto Municipal Hospital, Nanto, Toyama 932-0211, Japan. rsf14240@nifty.com
Key Words	Liver disease; Branched chain amino acids; Gene expression; Hepatocyte apoptosis; Hepatocyte regeneration; Immunity; Treatment
Core Tip	Advanced liver diseases are commonly accompanied by nutritional disturbances, which worsen the prognosis of the patients. Serum levels of branched-chain amino acids (BCAAs) are decreased in patients with liver cirrhosis, and the amino acids imbalance could affect the clinical picture of the disease and the prognosis of the patients. However, there are few comprehensive reviews on the biological activities of BCAAs. In this review, we summarize the biological activities of BCAAs, and discuss possible applications of BCAAs for the management of patients with advanced liver diseases with a list of clinical trials of BCAA administration.
Publish Date	2013-12-18 09:53
Citation	Tajiri K, Shimizu Y. Branched-chain amino acids in liver diseases. World J Gastroenterol 2013; 19(43): 7620-7629
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7620.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7620

Full Article (PDF)	WJG-19-7620.pdf
Manuscript File	4278-Review.doc
Answering Reviewers	4278-Answering reviewers.pdf
Copyright License Agreement	4278-Copyright assignment.docx
Non-Native Speakers of English Editing Certificate	4278-Language certificate.pdf
Peer-review Report	4278-Peer reviewer(s).pdf
Scientific Editor Work List	4278-Scientific editor work list.doc