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Articles Published Processes
8/16/2019 12:41:28 AM | Browse: 1127 | Download: 2971
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Received |
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2018-10-22 07:12 |
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Peer-Review Started |
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2018-10-23 02:58 |
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First Decision by Editorial Office Director |
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2018-11-27 18:57 |
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Return for Revision |
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2018-12-03 09:07 |
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Revised |
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2019-01-23 03:14 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-02-26 07:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-02-27 16:56 |
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Articles in Press |
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2019-02-27 16:56 |
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Edit the Manuscript by Language Editor |
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2019-03-27 18:39 |
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Typeset the Manuscript |
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2019-08-15 06:49 |
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Publish the Manuscript Online |
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2019-08-16 00:41 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Si-Si Li, Wei-Liang Jiang, Wen-Qin Xiao, Kai Li, Ye-Fei Zhang, Xing-Ya Guo, Yi-Qi Dai, Qiu-Yan Zhao, Ming-Jie Jiang, Zhan-Jun Lu and Rong Wan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Rong Wan, PhD, Chief Doctor, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Hongkou District, Shanghai 201620, China. doctorwanrong1970@126.com |
| Key Words |
Pancreatic neoplasms; Curcumin analog; Histone methyltransferase 2D; Therapeutic effects; Bioinformatics; |
| Core Tip |
We first report the anti-tumor effect of L48H37 in pancreatic cancer and ascertain that KMT2D deficiency contributed significantly to the therapeutic effect in part through the protein kinase RNA-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/activating transcription factor 4/CHOP signaling pathway. It's worth noting that the relationship between KMT2D expression pattern and treatment effectiveness in clinical practice has yet to be further explored. |
| Publish Date |
2019-08-16 00:41 |
| Citation |
Li SS, Jiang WL, Xiao WQ, Li K, Zhang YF, Guo XY, Dai YQ, Zhao QY, Jiang MJ, Lu ZJ, Wan R. KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma. World J Gastrointest Oncol 2019; 11(8): 599-621
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| URL |
https://www.wjgnet.com/1948-5204/full/v11/i8/599.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i8.599 |
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