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Articles Published Processes
1/14/2019 2:54:12 PM | Browse: 960 | Download: 1295
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Received |
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2018-10-12 10:36 |
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Peer-Review Started |
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2018-10-14 04:49 |
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To Make the First Decision |
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2018-11-15 03:54 |
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Return for Revision |
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2018-11-29 09:06 |
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Revised |
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2018-12-05 10:21 |
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Second Decision |
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2018-12-19 09:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-12-20 01:48 |
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Articles in Press |
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2018-12-20 01:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-12-24 04:05 |
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Typeset the Manuscript |
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2019-01-14 01:18 |
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Publish the Manuscript Online |
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2019-01-14 14:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Six-long non-coding RNA signature predicts recurrence-free survival in hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Xian Gu, Xing Zhang, Run-Chen Miao, Xiao-Hong Xiang, Yu-Nong Fu, Jing-Yao Zhang, Chang Liu and Kai Qu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Foundation of China |
81773128 |
| National Science Foundation of China |
81472247 |
| Natural Science Basic Research Plan in Shaanxi Province of China |
2017JM8039 |
| the Fundamental Research Fund for the Central Universities |
2016qngz05 |
| Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University |
XJTU1AF-CRF-2015-003 |
| Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University |
XJTU1AF-CRF-2015-011 |
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| Corresponding Author |
Kai Qu, MD, PhD, Associate Professor, Doctor, Doctor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an 710061, Shaanxi Province, China. joanne8601@163.com |
| Key Words |
Long non-coding RNAs; Hepatocellular carcinoma; Prognostic signature; Recurrence-free survival; Least absolute shrinkage and selection operator |
| Core Tip |
In this study, we constructed a six-lncRNA signature that could predict the recurrence-free survival (RFS) of hepatocellular carcinoma (HCC) via a novel formulation method - the least absolute shrinkage and selection operator (LASSO). LASSO, based on penalized regression, can handle all the independent variables simultaneously which has been demonstrated to be more accurate than stepwise regression. This lncRNA-signature was further validated and developed in another independent dataset from The Cancer Genome Atlas project. Our risk score system showed great utility in predicting the RFS of HCC and provided extra evidence for guiding targeted treatment of HCC. |
| Publish Date |
2019-01-14 14:54 |
| Citation |
Gu JX, Zhang X, Miao RC, Xiang XH, Fu YN, Zhang JY, Liu C, Qu K. Six-long non-coding RNA signature predicts recurrence-free survival in hepatocellular carcinoma. World J Gastroenterol 2019; 25(2): 220-232 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i2/220.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i2.220 |
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