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Articles Published Processes
1/14/2019 2:54:13 PM | Browse: 997 | Download: 1385
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Received |
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2018-10-12 10:39 |
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Peer-Review Started |
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2018-10-14 04:34 |
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To Make the First Decision |
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2018-11-15 03:51 |
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Return for Revision |
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2018-11-29 08:39 |
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Revised |
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2018-12-10 01:43 |
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Second Decision |
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2018-12-14 10:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-12-15 02:29 |
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Articles in Press |
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2018-12-15 02:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-12-20 12:45 |
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Typeset the Manuscript |
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2019-01-14 00:12 |
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Publish the Manuscript Online |
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2019-01-14 14:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Biomarker identification and trans-regulatory network analyses in esophageal adenocarcinoma and Barrett's esophagus
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Lv, Lei Guo, Ji-Han Wang, Yu-Zhu Yan, Jun Zhang, Yang-Yang Wang, Yan Yu, Yun-Fei Huang and He-Ping Zhao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
He-Ping Zhao, N/A, Chief Technician, Director, Director, Department of Clinical Laboratory, Honghui Hospital, Xi'an Jiaotong University, No.555 You Yi Xi Road, Xi'an 710054, Shaanxi Province, China. redcrossjyk@163.com |
| Key Words |
Barrett's esophagus; Esophageal adenocarcinoma; Differentially expressed genes; Transcription factors; Microarray |
| Core Tip |
We did comprehensive bioinformatics analyses to identify the differentially expressed genes in Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) samples from two Gene Expression Omnibus datasets, and certain potential biomarkers were revealed in the progression of BE and EAC. After trans-regulatory network prediction, receiver operating characteristic curve evaluation and Database for Annotation, Visualization and Integrated Discovery annotation, an association between COL1A1 and EAC was found. Similarly, an association between MMP1 and BE was also predicted. Our study provided a novel perspective on the molecular mechanisms involved in the development of BE and EAC. |
| Publish Date |
2019-01-14 14:54 |
| Citation |
Lv J, Guo L, Wang JH, Yan YZ, Zhang J, Wang YY, Yu Y, Huang YF, Zhao HP. Biomarker identification and trans-regulatory network analyses in esophageal adenocarcinoma and Barrett’s esophagus. World J Gastroenterol 2019; 25(2): 233-244 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i2/233.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i2.233 |
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