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Articles Published Processes
5/8/2019 7:47:20 AM | Browse: 903 | Download: 1377
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Received |
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2018-10-11 10:39 |
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Peer-Review Started |
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2018-10-12 09:20 |
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To Make the First Decision |
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2018-12-06 02:48 |
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Return for Revision |
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2018-12-18 06:02 |
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Revised |
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2019-01-08 19:18 |
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Second Decision |
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2019-03-08 08:12 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-12 15:08 |
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Articles in Press |
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2019-03-12 15:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-04-24 02:21 |
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Publish the Manuscript Online |
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2019-05-08 07:47 |
| ISSN |
2220-3168 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Loss of cavin1 and expression of p-caveolin-1 in pulmonary hypertension: Possible role in neointima formation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Huang and Rajamma Mathew |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Rajamma Mathew, MD, Associate Professor, Department of and Physiology, New York Medical College, 15 Dana Road, Rm A11, Basic science Building, Valhalla, NY 10595, United States. rajamma_mathew@nymc.edu |
| Key Words |
Caveolin-1; Cavin-1; Neointima; Phospho-caveolin1; Pulmonary hypertension |
| Core Tip |
Neointima leads to irreversible pulmonary hypertension (PH). Subjecting the monocrotaline (MCT)-injected rats to hypoxia accelerates the disease process; by 4 wk, neointima develops in arteries with extensive disruption of endothelial cells (EC), loss of endothelial caveolin-1 (cav-1), and enhanced cav-1 expression in smooth muscle cells. In addition, the MCT and MCT+ hypoxia groups exhibit significant loss of cavin-1 and the presence of tyrosine phosphorylated cav-1, which may facilitate cell migration and neointima formation. Hypoxia-induced PH does not exhibit EC disruption or alterations in cav-1 expression. Thus, EC integrity may determine the reversibility or irreversibility of PH. |
| Publish Date |
2019-05-08 07:47 |
| Citation |
Huang J, Mathew R. Loss of cavin1 and expression of p-caveolin-1 in pulmonary hypertension: Possible role in neointima formation. World J Hypertens 2019; 9(2): 17-29 |
| URL |
https://www.wjgnet.com/2220-3168/full/v9/i2/17.htm |
| DOI |
https://dx.doi.org/10.5494/wjh.v9.i2.17 |
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