| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Patricia Prieto, Rafael I Jaén, Daniel Calle, María Gómez-Serrano, Estefanía Núñez, María Fernández-Velasco, Paloma Martín-Sanz, Sergio Alonso, Jesús Vázquez, Sebastián Cerdán, Miguel Ángel Peinado and Lisardo Boscá |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| MINECO |
SAF2017-82436R, SAF2016-75004R |
| MINECO |
RTC-2017-6283-1, BIO2015-67580P |
| Comunidad de Madrid |
S2017/BMD-3686 |
| Fundación Ramón Areces |
2016/CIVP18A3864 |
| Instituto de Salud Carlos III, Spain, CIBERCV |
CB/11/00222 and CB16/11/00277 |
| Fondos FEDER |
CIBEREHD |
| Ministerio de Ciencia, Innovación y Universidades (MCNU) |
|
| Pro CNIC Foundation |
|
| Severo Ochoa Center of Excellence |
SEV-2015-0505 |
|
| Corresponding Author |
Lisardo Boscá, PhD, Professor, Department of Metabolism and Physiopathology of Inflammatory Diseases, Instituto de investigaciones Biomédicas “Alberto Sols”, Arturo Duperier 4, Madrid 28029, Spain. lbosca@iib.uam.es |
| Key Words |
Colon; Carcinoma; Cyclooxygenase; Prostaglandin; Proteomics; High resolution magic angle spinning |
| Core Tip |
Although increased levels of cyclooxygenase-2 (COX-2) have been broadly related to colorectal cancer (CRC), high variability exists among patients. In our cohort, the electrophoretic band profile of COX-2 was altered in tumor tissue due to COX-2 glycosylation. Furthermore, prostaglandin E2 levels in tumor tissue were significantly lower than in normal colonic mucosa. In order to further characterize these samples, we have also detected an altered metabolic and proteomic profile in the tumor samples compared to controls that can be associated with the presence of glycosylated COX-2. These findings contribute to delineate the post-translational complexity and heterogeneity of molecular signaling regulation in CRC progression. |
| Publish Date |
2019-01-26 11:40 |
| Citation |
Prieto P, Jaén RI, Calle D, Gómez-Serrano M, Núñez E, Fernández-Velasco M, Martín-Sanz P, Alonso S, Vázquez J, Cerdán S, Peinado MÁ, Boscá L. Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort. World J Gastroenterol 2019; 25(4): 433-446 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i4/433.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i4.433 |
