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6/14/2019 9:43:59 AM | Browse: 334 | Download: 203
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 42891
Country/Territory United States
2018-10-19 06:47
Peer-Review Started
2018-10-19 08:55
To Make the First Decision
2018-12-11 01:05
Return for Revision
2018-12-11 07:31
2019-03-07 19:52
Second Decision
2019-03-15 08:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-16 15:13
Articles in Press
2019-03-16 15:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-06-13 07:17
Publish the Manuscript Online
2019-06-14 09:43
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Plasma and wound fluid levels of eight proangiogenic proteins are elevated after colorectal resection
Manuscript Source Unsolicited Manuscript
All Author List HMC Shantha Kumara, Xiao-Hong Yan, Erica Pettke, Vesna Cekic, Nipa Dilip Gandhi, Geoffrey A Bellini and Richard L Whelan
Author(s) ORCID Number
HMC Shantha Kumara http://orcid.org/0000-0001-9106-797X
Xiao-Hong Yan http://orcid.org/0000-0001-8116-1161
Erica Pettke http://orcid.org/0000-0002-9841-939X
Vesna Cekic http://orcid.org/0000-0002-8130-6540
Nipa Dilip Gandhi http://orcid.org/0000-0003-4931-0432
Geoffrey A Bellini http://orcid.org/0000-0003-0912-8871
Richard L Whelan http://orcid.org/0000-0002-9707-4967
Funding Agency and Grant Number
Funding Agency Grant Number
Thompson Family Foundation
Corresponding author Richard L Whelan, MD, Attending Doctor, Full Professor, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, Suite 7B, 425 West, 59th Street, New York, NY 10019, United States. richard.whelan@mountsinai.org
Key Words Effects of surgery; Colorectal resection; Colorectal cancer; Plasma protein levels; Wound protein levels; Angiogenesis
Core Tip Simultaneous postoperative (postop) measurement of plasma and wound fluid levels of 8 proangiogenic proteins for 3 wk after colorectal resection was carried out in 66 patients. Wound fluid protein levels were 3-106 times greater than postop plasma levels which, in turn, were significantly greater than preoperative plasma levels. Colorectal resection is associated with persistent systemic blood protein changes that might stimulate tumor angiogenesis and, thus, tumor growth in residual tumor deposits during the first month after surgery. It is hypothesized that the healing wounds are a major source of the added protein in the blood stream.
Publish Date 2019-06-14 09:43
Citation Shantha Kumara HMC, Yan XH, Pettke E, Cekic V, Gandhi ND, Bellini GA, Whelan RL. Plasma and wound fluid levels of eight proangiogenic proteins are elevated after colorectal resection. World J Gastrointest Oncol 2019; 11(6): 470-488
Url https://www.wjgnet.com/1948-5204/full/v11/i6/470.htm
DOI https://dx.doi.org/10.4251/wjgo.v11.i6.470
Full Article (PDF) WJGO-11-470.pdf
Manuscript File 42891-Review.doc
Answering Reviewers 42891-Answering reviewers.pdf
Audio Core Tip 42891-Audio core tip.m4a
Biostatistics Review Certificate 42891-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42891-Conflict-of-interest statement.pdf
Copyright License Agreement 42891-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42891-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 42891-Institutional review board statement.pdf
Supplementary Material 42891-Supplementary material.pdf
Peer-review Report 42891-Peer-review(s).pdf
Scientific Misconduct Check 42891-Scientific misconduct check.pdf
Scientific Editor Work List 42891-Scientific editor work list.pdf