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Articles Published Processes
6/14/2019 9:43:59 AM | Browse: 1089 | Download: 1340
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Received |
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2018-10-19 06:47 |
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Peer-Review Started |
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2018-10-19 08:55 |
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To Make the First Decision |
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2018-12-11 01:05 |
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Return for Revision |
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2018-12-11 07:31 |
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Revised |
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2019-03-07 19:52 |
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Second Decision |
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2019-03-15 08:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-16 15:13 |
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Articles in Press |
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2019-03-16 15:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-06-13 07:17 |
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Publish the Manuscript Online |
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2019-06-14 09:43 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Plasma and wound fluid levels of eight proangiogenic proteins are elevated after colorectal resection
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
HMC Shantha Kumara, Xiao-Hong Yan, Erica Pettke, Vesna Cekic, Nipa Dilip Gandhi, Geoffrey A Bellini and Richard L Whelan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Thompson Family Foundation |
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| Corresponding Author |
Richard L Whelan, MD, Attending Doctor, Full Professor, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, Suite 7B, 425 West, 59th Street, New York, NY 10019, United States. richard.whelan@mountsinai.org |
| Key Words |
Effects of surgery; Colorectal resection; Colorectal cancer; Plasma protein levels; Wound protein levels; Angiogenesis |
| Core Tip |
Simultaneous postoperative (postop) measurement of plasma and wound fluid levels of 8 proangiogenic proteins for 3 wk after colorectal resection was carried out in 66 patients. Wound fluid protein levels were 3-106 times greater than postop plasma levels which, in turn, were significantly greater than preoperative plasma levels. Colorectal resection is associated with persistent systemic blood protein changes that might stimulate tumor angiogenesis and, thus, tumor growth in residual tumor deposits during the first month after surgery. It is hypothesized that the healing wounds are a major source of the added protein in the blood stream. |
| Publish Date |
2019-06-14 09:43 |
| Citation |
Shantha Kumara HMC, Yan XH, Pettke E, Cekic V, Gandhi ND, Bellini GA, Whelan RL. Plasma and wound fluid levels of eight proangiogenic proteins are elevated after colorectal resection. World J Gastrointest Oncol 2019; 11(6): 470-488 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i6/470.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i6.470 |
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