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Publication Name World Journal of Gastroenterology
Manuscript ID 4291
Country/Territory Italy
Received
2013-06-26 08:39
Peer-Review Started
2013-06-26 17:23
To Make the First Decision
2013-07-19 08:40
Return for Revision
2013-07-20 14:03
Revised
2013-07-30 22:47
Second Decision
2013-08-16 19:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-08-16 23:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-10-13 17:20
Publish the Manuscript Online
2013-11-08 14:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Editorial
Article Title Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease
Manuscript Source Invited Manuscript
All Author List Michele Cicala, Sara Emerenziani, Michele Pier Luca Guarino and Mentore Ribolsi
Funding Agency and Grant Number
Corresponding author Michele Cicala, MD, PhD, Unit of Digestive Disease, Campus Bio Medico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy. m.cicala@unicampus.it
Keywords Gastro-esophageal reflux disease; Proton pump inhibitor; Ambulatory pH-impedance monitoring; Esophageal hypersensitivity; Gastro-esophageal reflux disease treatment
Core Tip The present review focuses on the subgroup of patients in whom proton pump inhibitor refractoriness more frequently occurs, on the mechanisms possibly involved in the lack of response, the diagnostic work-up and the therapeutic strategies in these patients. Various mechanisms and factors have been demonstrated and some mechanisms have also been proposed, although not yet supported by strong evidence. In the management of these patients, a careful clinical interview might conduct the diagnostic evaluation and the therapeutic approaches.
Publish Date 2013-11-08 14:06
Citation Cicala M, Emerenziani S, Guarino MPL, Ribolsi M. Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease. World J Gastroenterol 2013; 19(39): 6529-6535
Url http://www.wjgnet.com/1007-9327/full/v19/i39/6529.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i39.6529
Full Article (PDF) WJG-19-6529.pdf
Manuscript File 4291-Review.doc
Answering Reviewers 4291-Answering reviewers.pdf
Copyright License Agreement 4291-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 4291-Language certificate.pdf
Peer-review Report 4291-Peer review(s).pdf
Scientific Editor Work List 4291-Scientific editor work list.doc