Publication Name	World Journal of Gastroenterology
Manuscript ID	4291
Country	Italy

Received	2013-06-26 08:39
Peer-Review Started	2013-06-26 17:23
To Make the First Decision	2013-07-19 08:40
Return for Revision	2013-07-20 14:03
Revised	2013-07-30 22:47
Second Decision	2013-08-16 19:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-16 23:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-13 17:20
Publish the Manuscript Online	2013-11-08 14:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease
Manuscript Source	Invited Manuscript
All Author List	Michele Cicala, Sara Emerenziani, Michele Pier Luca Guarino and Mentore Ribolsi
Funding Agency and Grant Number
Corresponding Author	Michele Cicala, MD, PhD, Unit of Digestive Disease, Campus Bio Medico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy. m.cicala@unicampus.it
Key Words	Gastro-esophageal reflux disease; Proton pump inhibitor; Ambulatory pH-impedance monitoring; Esophageal hypersensitivity; Gastro-esophageal reflux disease treatment
Core Tip	The present review focuses on the subgroup of patients in whom proton pump inhibitor refractoriness more frequently occurs, on the mechanisms possibly involved in the lack of response, the diagnostic work-up and the therapeutic strategies in these patients. Various mechanisms and factors have been demonstrated and some mechanisms have also been proposed, although not yet supported by strong evidence. In the management of these patients, a careful clinical interview might conduct the diagnostic evaluation and the therapeutic approaches.
Publish Date	2013-11-08 14:06
Citation	Cicala M, Emerenziani S, Guarino MPL, Ribolsi M. Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease. World J Gastroenterol 2013; 19(39): 6529-6535
URL	http://www.wjgnet.com/1007-9327/full/v19/i39/6529.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i39.6529

Full Article (PDF)	WJG-19-6529.pdf
Manuscript File	4291-Review.doc
Answering Reviewers	4291-Answering reviewers.pdf
Copyright License Agreement	4291-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4291-Language certificate.pdf
Peer-review Report	4291-Peer review(s).pdf
Scientific Editor Work List	4291-Scientific editor work list.doc