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Articles Published Processes
1/7/2019 10:39:41 AM | Browse: 1136 | Download: 1398
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Received |
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2018-10-19 01:57 |
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Peer-Review Started |
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2018-10-19 05:28 |
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To Make the First Decision |
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2018-11-29 09:18 |
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Return for Revision |
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2018-11-30 03:51 |
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Revised |
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2018-12-07 17:12 |
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Second Decision |
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2018-12-13 09:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-12-13 17:40 |
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Articles in Press |
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2018-12-13 17:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-12-24 01:22 |
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Typeset the Manuscript |
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2019-01-06 10:19 |
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Publish the Manuscript Online |
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2019-01-07 10:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shahab Mahmoudvand, Somayeh Shokri, Reza Taherkhani and Fatemeh Farshadpour |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Fatemeh Farshadpour, PhD, Associate Professor, Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Moallem Street, Bushehr 7514633341, Iran. f.farshadpour@bpums.ac.ir |
| Key Words |
Hepatitis C virus; Core protein; Transforming growth factor β; Vascular endothelial growth factor; Wnt/β-catenin; Cyclooxygenase-2; Peroxisome proliferator-activated receptor α; Hepatocellular carcinoma |
| Core Tip |
Hepatitis C virus (HCV) core protein can modulate several signaling pathways involved in cell cycle regulation, cell growth promotion, cell proliferation, apoptosis, oxidative stress and lipid metabolism. The dysregulation of these signaling pathways by HCV core protein is implicated in the development of hepatocellular carcinoma (HCC). Considering the axial role of these signaling pathways in HCC, they are considered druggable targets for cancer therapy. Therefore, using strategies to limit the dysregulation effects of core protein on these signaling pathways seems necessary to prevent HCV-related HCC. |
| Publish Date |
2019-01-07 10:39 |
| Citation |
Mahmoudvand S, Shokri S, Taherkhani R, Farshadpour F. Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma. World J Gastroenterol 2019; 25(1): 42-58 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i1/42.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i1.42 |
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