Publication Name	World Journal of Stem Cells
Manuscript ID	43045
Country	Poland

Received	2018-10-27 06:50
Peer-Review Started	2018-10-27 11:49
To Make the First Decision	2018-11-16 01:50
Return for Revision	2018-11-19 08:36
Revised	2018-12-03 09:51
Second Decision	2019-01-26 10:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-01-26 23:47
Articles in Press	2019-01-26 23:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-06-26 08:15
Publish the Manuscript Online	2019-06-26 11:43

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues
Manuscript Source	Invited Manuscript
All Author List	Urszula Kozlowska, Agnieszka Krawczenko, Katarzyna Futoma, Tomasz Jurek, Marta Rorat, Dariusz Patrzalek and Aleksandra Klimczak
ORCID	Author(s) ORCID Number Urszula Kozlowska http://orcid.org/0000-0003-0213-0215 Agnieszka Krawczenko http://orcid.org/0000-0003-4545-8843 Katarzyna Futoma http://orcid.org/0000-0003-3956-4914 Tomasz Jurek http://orcid.org/0000-0003-0110-0276 Marta Rorat http://orcid.org/0000-0002-5318-4945 Dariusz Patrzalek http://orcid.org/0000-0003-0111-263X Aleksandra Klimczak http://orcid.org/0000-0001-6590-4420
Funding Agency and Grant Number	Funding Agency Grant Number National Science Center of Poland N N407121940 Wroclaw Centre of Biotechnology, programme The Leading National Research Centre (KNOW) for years 2014-2018
Corresponding Author	Aleksandra Klimczak, DSc, PhD, Associate Professor, Laboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences, Rudolfa Weigla 12 Street, Wrocław 53-114, Poland. klimczak@iitd.pan.wroc.pl
Key Words	Mesenchymal stem/progenitor cells; Bone marrow MSCs; Adipose tissue MSCs; Muscle-derived MSCs; Skin-derived MSCs; Cytokines and trophic factors of MSCs; Spontaneous fusion of MSCs
Core Tip	A comprehensive characterization of Mesenchymal stromal/stem cells (MSCs) with different tissue origin during long-term culture was demonstrated in terms of: basic phenotype strength, stemness and genetic stability, and ability to secrete bioactive factors and affect one another in co-culture. MSCs were phenotypically heterogeneous and showed diverse differentiation potentials and secretion of bioactive factors associated with tissue origin. BM MSCs and AT-MSCs expressed stemness markers Sox2 and Oct4 in long-term culture, whereas SM-MSCs and SK-MSCs did not. All MSCs were stable for p53 and c-Myc expression. AT-MSCs fused with SM-MSCs as effectively as BM-MSCs. Long-term culture affected the biological properties of the MSCs.
Publish Date	2019-06-26 11:43
Citation	Kozlowska U, Krawczenko A, Futoma K, Jurek T, Rorat M, Patrzalek D, Klimczak A. Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues. World J Stem Cells 2019; 11(6): 347-374
URL	https://www.wjgnet.com/1948-0210/full/v11/i6/347.htm
DOI	https://dx.doi.org/10.4252/wjsc.v11.i6.347

Full Article (PDF)	WJSC-11-347.pdf
Full Article (Word)	WJSC-11-347.docx
The ARRIVE Guidelines	43045-The ARRIVE Guidelines.pdf
Manuscript File	43045-Review.docx
Answering Reviewers	43045-Answering reviewers.pdf
Audio Core Tip	43045-Audio core tip.mp3
Biostatistics Review Certificate	43045-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	43045-Conflict-of-interest statement.pdf
Copyright License Agreement	43045-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	43045-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	43045-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	43045-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	43045-Language certificate.pdf
Video	43045-Video-revision.pdf
Supplementary Material	43045-Supplementary-Material-revision.pdf
Peer-review Report	43045-Peer-review(s).pdf
Scientific Misconduct Check	43045-Scientific misconduct check.pdf
Scientific Editor Work List	43045-Scientific editor work list.pdf