Publication Name	World Journal of Hepatology
Manuscript ID	4306
Country	Italy

Received	2013-06-26 10:32
Peer-Review Started	2013-06-26 16:00
To Make the First Decision	2013-07-19 08:39
Return for Revision	2013-07-20 13:54
Revised	2013-08-06 04:56
Second Decision	2013-09-13 15:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-13 22:55
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-23 18:55
Publish the Manuscript Online	2013-10-25 08:47

ISSN	1948-5182 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Chronic HCV infection and inflammation: Clinical impact on hepatic and extra-hepatic manifestations
Manuscript Source	Invited Manuscript
All Author List	Rosa Zampino, Aldo Marrone, Luciano Restivo, Barbara Guerrera, Ausilia Sellitto, Luca Rinaldi, Ciro Romano and Luigi E Adinolfi
Funding Agency and Grant Number	Funding Agency Grant Number Regione Campania
Corresponding Author	Luigi E Adinolfi, MD, Professor, Head of Internal Medicine, Second University of Naples, Clinical Hospital of Marcianise, Caserta Local Health Unit, Corso Umberto I, 179, 81100 Marcianise, Italy. luigielio.adinolfi@unina2.it
Key Words	Hepatitis C virus; Inflammation; Cytokines; Oxidative stress; Hepatic disease; Extra-hepatic diseases
Core Tip	Chronic hepatitis C virus (HCV) infection causes liver inflammation by complex and not yet well-understood molecular pathways. HCV-induced inflammation has a significant clinical impact on development of both hepatic disease and HCV-associated extrahepatic manifestations. Knowledge of the complex mechanisms underlying HCV-related inflammation and development of disease as well as individuation of relevant markers of inflammation could be of importance for understanding disease progression, predicting prognosis and, possibly, conceiving new therapeutic approaches targeting the different steps of the inflammatory response.
Publish Date	2013-10-25 08:47
Citation	Zampino R, Marrone A, Restivo L, Guerrera B, Sellitto A, Rinaldi L, Romano C, Adinolfi LE. Chronic HCV infection and inflammation: Clinical impact on hepatic and extra-hepatic manifestations. World J Hepatol 2013; 5(10): 528-540
URL	http://www.wjgnet.com/1948-5182/full/v5/i10/528.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i10.528

Full Article (PDF)	WJH-5-528.pdf
Manuscript File	4306-Review.doc
Answering Reviewers	4306-Answering reviewers.pdf
Copyright License Agreement	4306-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4306-Language certificate.pdf
Peer-review Report	4306-Peer review(s).pdf
Scientific Editor Work List	4306-Scientific editor work list.doc