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Articles Published Processes
1/30/2019 5:59:07 AM | Browse: 1088 | Download: 1772
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Received |
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2018-10-24 06:07 |
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Peer-Review Started |
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2018-10-25 01:59 |
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To Make the First Decision |
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2018-11-29 09:30 |
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Return for Revision |
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2018-12-17 07:16 |
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Revised |
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2019-01-10 06:42 |
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Second Decision |
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2019-01-18 11:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-01-18 23:04 |
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Articles in Press |
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2019-01-18 23:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-01-23 01:35 |
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Typeset the Manuscript |
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2019-01-29 06:56 |
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Publish the Manuscript Online |
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2019-01-30 05:59 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Claudin-7 gene knockout causes destruction of intestinal structure and animal death in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chang Xu, Kun Wang, Yu-Han Ding, Wen-Jing Li and Lei Ding |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81372585 |
| National Natural Science Foundation of China |
81772557 |
| Beijing Health System High Level Training Plan of Health Technical Personnel |
2014-3-048 |
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| Corresponding Author |
Lei Ding, MD, PhD, Associate Professor, Chief Doctor, Surgeon, Surgical Oncologist, Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Tieyi Road 10, Haidian District, Beijing 100038, China. dinglei1005@126.com |
| Key Words |
Claudin-7; Gene knockout; Inflammation; Adenomas; Colorectal carcinoma |
| Core Tip |
The intestinal tract of conventional and intestinal specific Claudin-7 knockout mice was characterized by extensive and severe inflammation. The development of inducible conditional knockout mice can control the knockout of Claudin-7 in a temporal and compartment specific manner and prolong the survival time of mice, which exhibited atypical hyperplasia and adenoma in the intestine. This study revealed the inhibitory role that Claudin-7 plays in colorectal inflammation and colorectal cancer. |
| Publish Date |
2019-01-30 05:59 |
| Citation |
Xu C, Wang K, Ding YH, Li WJ, Ding L. Claudin-7 gene knockout causes destruction of intestinal structure and animal death in mice. World J Gastroenterol 2019; 25(5): 584-599 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i5/584.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i5.584 |
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