| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Relationship between Fusobacterium nucleatum, inflammatory mediators and microRNAs in colorectal carcinogenesis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Marcela Alcântara Proença, Joice Matos Biselli, Maysa Succi, Fábio Eduardo Severino, Gustavo Noriz Berardinelli, Alaor Caetano, Rui Manuel Reis, David J Hughes and Ana Elizabete Silva |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| São Paulo Research Foundation (FAPESP) |
2012/15036-8 |
| National Council for Scientific and Technological Development (CNPq) |
474.776/2013-1 |
|
| Corresponding Author |
Ana Elizabete Silva, PhD, Adjunct Professor, Teacher, Department of Biology, UNESP São Paulo State University, Rua Cristóvão Colombo 2265, São José do Rio Preto 15054-000, São Paulo, Brazil. ae.silva@ibilce.unesp.br |
| Key Words |
Colorectal cancer; Colorectal adenoma; Fusobacterium nucleatum; Inflammation; Cytokines; MicroRNAs |
| Core Tip |
We examined the influence of Fusobacterium nucleatum (F. nucleatum) in colorectal adenoma (CRA) and colorectal cancer (CRC) on the mRNA expression of inflammatory mediators and the association with microRNA (miRNA) levels, KRAS mutation, and microsatellite instability (MSI). We suggest that F. nucleatum contributes to CRC development by increasing the expression of inflammatory mediators through a possible miRNA-mediated activation of TLR2/TLR4. The miRNA:mRNA interaction network suggests an upregulation of miR-34a in CRC via a TLR2/TLR4-dependent response to F. nucleatum. KRAS mutations were more frequent in F. nucleatum-infected CRC and were associated with a greater expression of miR-21 in CRA, while IL8 was upregulated in MSI-high CRC. |
| Publish Date |
2018-12-21 10:07 |
| Citation |
Proença MA, Biselli JM, Succi M, Severino FE, Berardinelli GN, Caetano A, Reis RM, Hughes DJ, Silva AE. Relationship between Fusobacterium nucleatum, inflammatory mediators and microRNAs in colorectal carcinogenesis. World J Gastroenterol 2018; 24(47): 5351-5365 |
| URL |
https://www.wjgnet.com/1007-9327/full/v24/i47/5351.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v24.i47.5351 |
