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Articles Published Processes
3/27/2019 10:37:20 AM | Browse: 1239 | Download: 2369
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Received |
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2018-10-30 01:13 |
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Peer-Review Started |
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2018-10-30 08:17 |
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To Make the First Decision |
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2018-12-11 00:55 |
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Return for Revision |
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2018-12-21 02:58 |
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Revised |
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2019-02-22 03:07 |
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Second Decision |
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2019-03-08 08:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-12 15:28 |
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Articles in Press |
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2019-03-12 15:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-03-27 05:37 |
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Publish the Manuscript Online |
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2019-03-27 10:37 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Protective action of glutamine in rats with severe acute liver failure
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Elizângela G Schemitt, Renata M Hartmann, Josieli R Colares, Francielli Licks, Jéferson O Salvi, Cláudio A Marroni and Norma Possa Marroni |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Cláudio A Marroni, MD, PhD, Doctor, Doctor, Laboratory of Experimental Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Rua José Kanan Aranha 102, Porto Alegre 91760470, Brazil. nmarroni@terra.com.br |
| Key Words |
Thioacetamide; Cytokines; Oxidative stress; Inflammation; Liver failure; Chemical and drug induced liver injury; Glutamine |
| Core Tip |
Severe acute liver failure (SALF) is a rare syndrome characterized by rapid deterioration of liver function, usually in patients without underlying liver disease; the only effective treatment is transplantation. In this study, we used thioacetamide (TAA), a known xenobiotic hepatotoxicant, to induce SALF in rats. This was followed by administration of glutamine in an attempt to activate antioxidative defenses via the erythroid 2-related factor 2 (Nrf2) pathway and mitigate liver injury. Glutamine successfully activated Nrf2 and inhibited TLR4/NFB-mediated inflammation, allowing restoration of parenchymal architecture and recovery of several parameters to near-control levels. |
| Publish Date |
2019-03-27 10:37 |
| Citation |
Schemitt EG, Hartmann RM, Colares JR, Licks F, Salvi JO, Marroni CA, Marroni NP. Protective action of glutamine in rats with severe acute liver failure. World J Hepatol 2019; 11(3): 273-286 |
| URL |
https://www.wjgnet.com/1948-5182/full/v11/i3/273.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v11.i3.273 |
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