Publication Name	World Journal of Respirology
Manuscript ID	4329
Country	United States

Received	2013-06-27 11:47
Peer-Review Started	2013-06-27 17:25
To Make the First Decision	2013-07-05 18:35
Return for Revision	2013-07-08 16:46
Revised	2013-07-09 04:17
Second Decision	2013-07-18 14:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-19 01:12
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-26 13:27
Publish the Manuscript Online	2013-12-03 15:44

ISSN	2218-6255 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Respiratory System
Manuscript Type	Review
Article Title	Von Hippel-Lindau protein and respiratory diseases
Manuscript Source	Invited Manuscript
All Author List	Tianji Chen, Miranda Sun and Guofei Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Pulmonary Hypertension Association and American Lung Association to Dr. Guofei Zhou
Corresponding Author	Guofei Zhou, PhD, Department of Pediatrics, University of Illinois at Chicago, University of Illinois Hospital and Health Sciences System, 840 S. Wood Street, M/C 856, Ste 1206, Chicago, IL 60612, United States. guofei@uic.edu
Key Words	Von Hippel-Lindau protein; Lung cancer; Pulmonary fibrosis; Pulmonary hypertension
Core Tip	Although von Hippel-Lindau protein (pVHL) was first identified as a tumor suppressor and is best known as a component of ubiquitin protein ligase for the proteasomal degradation of hypoxia inducible factor (HIF)-?, recent studies suggest that pVHL contributes to many lung diseases in both HIF-dependent and HIF-independent pathways. Loss of pVHL promotes pulmonary arterial hypertension via activation of HIF. In lung cancer, loss of pVHL promotes epithelial-mesenchymal transition and cancer migration and invasion while decreasing cell proliferation and colonization. pVHL also induces fibronectin/integrin ?5?1/focal adhesion kinase signaling to facilitate fibrogenesis. pVHL mediates Na-K-ATPase degradation to cause decreased edema clearance during hypoxia.
Publish Date	2013-12-03 15:44
Citation	Chen T, Sun M, Zhou G. Von Hippel-Lindau protein and respiratory diseases. World J Respirol 2013; 3(3): 48-56
URL	http://www.wjgnet.com/2218-6255/full/v3/i3/48.htm
DOI	http://dx.doi.org/10.5320/wjr.v3.i3.48

Full Article (PDF)	WJR-3-48.pdf
Manuscript File	4329-Review.doc
Answering Reviewers	4329-Answering reviewers.pdf
Copyright License Agreement	4329-Copyright assignment.pdf
Peer-review Report	4329-Peer review(s).pdf
Scientific Editor Work List	4329-Scientific editor work list.doc