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Articles Published Processes
2/26/2019 8:24:54 AM | Browse: 699 | Download: 828
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Received |
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2018-11-02 01:58 |
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Peer-Review Started |
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2018-11-02 09:13 |
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To Make the First Decision |
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2019-01-14 03:21 |
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Return for Revision |
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2019-01-15 02:24 |
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Revised |
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2019-02-23 06:28 |
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Second Decision |
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2019-02-25 04:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-02-25 05:44 |
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Articles in Press |
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2019-02-25 05:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-02-26 00:18 |
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Publish the Manuscript Online |
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2019-02-26 08:24 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
In vivo expression of thrombospondin-1 suppresses the formation of peritoneal adhesion in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun-Sheng Tai, I-Ming Jou, Yun-Chih Jung, Chao-Liang Wu, Ai-Li Shiau and Chih-Yi Chen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chih-Yi Chen, MD, PhD, Doctor, Doctor, Professor, Institute of Medicine, Department of Surgery, Chung Shan Medical University Hospital, No.110, Sec.1, Jianguo N.Rd,, Taichung 402, Taiwan. neuron6599@gmail.com |
| Key Words |
Intraperitoneal adhesions; Thrombospondin 1; Rat model |
| Core Tip |
Formation of intraperitoneal adhesions is one of the major complications after abdominal surgery, which may lead to bowel obstruction. Thrombospondin-1 (TSP-1) is an extracellular matrix modulating glycoprotein during tissue regeneration and collagen deposition. This study evaluated the therapeutic potential of overexpressed TSP-1 in suppressing pelvic adhesion formations in rat models. We found the application of Sperafilm reduced the formation of adhesion band, and local administration of adenoviral vectors encoding TSP-1 on the injured cecum the also attenuated the severity of peritoneal adhesion score. Therefore, therapeutic approaches in inducing regional overexpression of TSP-1 may serve as alternative treatment strategies for preventing postoperative peritoneal adhesion. |
| Publish Date |
2019-02-26 08:24 |
| Citation |
Tai YS, Jou IM, Jung YC, Wu CL, Shiau AL, Chih-Yi Chen CY. In vivo expression of thrombospondin-1 suppresses the formation of peritoneal adhesion in rats. World J Gastrointest Surg 2019; 11(2): 85-92 |
| URL |
ttps://www.wjgnet.com/1948-9366/full/v11/i2/85.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v11.i2.85 |
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