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Articles Published Processes
3/26/2019 7:46:36 AM | Browse: 796 | Download: 1645
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Received |
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2018-11-14 03:23 |
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Peer-Review Started |
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2018-11-15 00:30 |
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To Make the First Decision |
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2018-12-11 01:14 |
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Return for Revision |
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2018-12-17 03:01 |
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Revised |
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2018-12-19 03:05 |
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Second Decision |
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2019-01-26 09:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-01-26 23:37 |
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Articles in Press |
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2019-01-26 23:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-02-03 09:09 |
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Typeset the Manuscript |
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2019-03-26 04:06 |
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Publish the Manuscript Online |
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2019-03-26 07:46 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Stromal cell-derived factor-1α promotes recruitment and differentiation of nucleus pulposus-derived stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jin-Wei Ying, Tian-Yong Wen, Shi-Shen Pei, Ling-Hao Su and Di-Ke Ruan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81772399 |
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| Corresponding Author |
Di-Ke Ruan, PhD, Chief Doctor, Doctor, Doctor, Surgeon, the Second School of Clinical Medicine, Southern Medical University, South Sha-Tai Road, Guangzhou 510515, Guangdong Province, China. ruandikengh@163.com |
| Key Words |
Stromal cell-derived factor 1α; CXC chemokine receptor 4; Nucleus pulposus-derived stem cells; Intervertebral disc degeneration; Endogenous regeneration |
| Core Tip |
The chemokine stromal cell-derived factor-1α (SDF-1α) is upregulated in the pro-inflammatory microenvironment or degenerative intervertebral disc (IVD). The present study demonstrates for the first time that SDF-1α effectively promotes migration and chondrogenic differentiation of nucleus pulposus-derived stem cells (NPSCs), which serve as endogenous progenitor/stem cells residing in IVD. In addition, SDF-1/CXCR4 chemotaxis signals may play a crucial role in the process of recruitment and chondrogenic differentiation of NPSCs that are involved in spontaneous IVD regeneration in the early stage of IVD degeneration. |
| Publish Date |
2019-03-26 07:46 |
| Citation |
Ying JW, Wen TY, Pei SS, Su LH, Ruan DK. Stromal cell-derived factor-1α promotes recruitment and differentiation of nucleus pulposus-derived stem cells. World J Stem Cells 2019; 11(3): 196-211 |
| URL |
https://www.wjgnet.com/1948-0210/full/v11/i3/196.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v11.i3.196 |
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