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3/26/2019 7:46:36 AM | Browse: 329 | Download: 361
Publication Name World Journal of Stem Cells
Manuscript ID 43395
Country/Territory China
2018-11-14 03:23
Peer-Review Started
2018-11-15 00:30
To Make the First Decision
2018-12-11 01:14
Return for Revision
2018-12-17 03:01
2018-12-19 03:05
Second Decision
2019-01-26 09:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-26 23:37
Articles in Press
2019-01-26 23:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-02-03 09:09
Typeset the Manuscript
2019-03-26 04:06
Publish the Manuscript Online
2019-03-26 07:46
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title Stromal cell-derived factor-1α promotes recruitment and differentiation of nucleus pulposus-derived stem cells
Manuscript Source Invited Manuscript
All Author List Jin-Wei Ying, Tian-Yong Wen, Shi-Shen Pei, Ling-Hao Su and Di-Ke Ruan
Author(s) ORCID Number
Jin-Wei Ying http://orcid.org/0000-0003-0966-0112
Tian-Yong Wen http://orcid.org/0000-0002-6193-8313
Shi-Shen Pei http://orcid.org/0000-0003-0327-1423
Ling-Hao Su http://orcid.org/0000-0003-4610-7834
Di-Ke Ruan http://orcid.org/0000-0002-9642-3096
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81772399
Corresponding Author Di-Ke Ruan, PhD, Chief Doctor, Doctor, Surgeon, the Second School of Clinical Medicine, Southern Medical University, South Sha-Tai Road, Guangzhou 510515, Guangdong Province, China. ruandikengh@163.com
Key Words Stromal cell-derived factor 1α; CXC chemokine receptor 4; Nucleus pulposus-derived stem cells; Intervertebral disc degeneration; Endogenous regeneration
Core Tip The chemokine stromal cell-derived factor-1α (SDF-1α) is upregulated in the pro-inflammatory microenvironment or degenerative intervertebral disc (IVD). The present study demonstrates for the first time that SDF-1α effectively promotes migration and chondrogenic differentiation of nucleus pulposus-derived stem cells (NPSCs), which serve as endogenous progenitor/stem cells residing in IVD. In addition, SDF-1/CXCR4 chemotaxis signals may play a crucial role in the process of recruitment and chondrogenic differentiation of NPSCs that are involved in spontaneous IVD regeneration in the early stage of IVD degeneration.
Publish Date 2019-03-26 07:46
Citation Ying JW, Wen TY, Pei SS, Su LH, Ruan DK. Stromal cell-derived factor-1α promotes recruitment and differentiation of nucleus pulposus-derived stem cells. World J Stem Cells 2019; 11(3): 196-211
URL https://www.wjgnet.com/1948-0210/full/v11/i3/196.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i3.196
Full Article (PDF) WJSC-11-196.pdf
Full Article (Word) WJSC-11-196.docx
Manuscript File 43395-Review_Edited.docx
Answering Reviewers 43395-Answering reviewers.pdf
Audio Core Tip 43395-Audio core tip.mp3
Biostatistics Review Certificate 43395-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 43395-Conflict-of-interest statement.pdf
Copyright License Agreement 43395-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 43395-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 43395-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 43395-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 43395-Language certificate.pdf
Peer-review Report 43395-Peer-review(s).pdf
Scientific Misconduct Check 43395-Scientific misconduct check.pdf
Scientific Editor Work List 43395-Scientific editor work list.pdf