| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus
|
| Manuscript Source |
Invited Conference Manuscripts |
| All Author List |
Tarek Besheer, Hatem Elalfy, Mohamed Abd El-Maksoud, Ahmed Abd El-Razek, Saher Taman, Khaled Zalata, Wagdy Elkashef, Hosam Zaghloul, Heba Elshahawy, Doaa Raafat, Wafaa Elemshaty, Eman Elsayed, Abdel-Hady El-Gilany and Mahmoud El-Bendary |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Development Foundation |
3457 |
|
| Corresponding Author |
Mahmoud El-Bendary, MD, Professor, Department of Tropical Medicine and Hepatology, Mansoura Faculty of Medicine—Mansoura University, Elgomhoria Street, Mansoura 35111, Dakahlia, Egypt. mmelbendary@gmail.com;mm_elbendary@mans.edu.eg |
| Key Words |
Diffusion; Magnetic resonance imaging; Fibrosis; Liver; Hepatitis C virus; Micro-RNA |
| Core Tip |
We aimed to assess diffusion-weighted magnetic resonance imaging and micro-RNAs in diagnosis and staging of hepatic fibrosis. Patients underwent DWI of the abdomen, micro-RNA profiling, and liver biopsy. The apparent diffusion coefficient (ADC) and miR were calculated and correlated with METAVIR score. We found that ADC value was decreased from controls (F0) to patients with early fibrosis and those with late fibrosis. Combined ADC and miR-200b revealed the best result for differentiating early from late fibrosis and offer an alternative surrogate non-invasive diagnostic tool for diagnosis and staging of hepatic fibrosis in patients with chronic hepatitis C. |
| Publish Date |
2019-03-20 05:32 |
| Citation |
Besheer T, Elalfy H, Abd El-Maksoud M, Abd El-Razek A, Taman S, Zalata K, Elkashef W, Zaghloul H, Elshahawy H, Raafat D, Elemshaty W, Elsayed E, El-Gilany AH, El-Bendary M. Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus. World J Gastroenterol 2019; 25(11): 1366-1377 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i11/1366.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i11.1366 |
