Publication Name	World Journal of Gastroenterology
Manuscript ID	4356
Country	Italy

Received	2013-06-28 10:02
Peer-Review Started	2013-06-28 15:52
First Decision by Editorial Office Director
Return for Revision	2013-07-31 10:47
Revised	2013-08-07 22:02
Publication Fee Transferred
Second Decision by Editor	2013-08-29 07:59
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-08-29 10:13
Articles in Press
Edit the Manuscript by Language Editor	2013-09-08 01:19
Typeset the Manuscript	2013-10-29 11:32
Publish the Manuscript Online	2013-11-16 18:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Neuromodulation for fecal incontinence: An effective surgical intervention
Manuscript Source	Invited Manuscript
All Author List	Giuseppe Chiarioni, Olafur S Palsson, Corrado R Asteria and William E Whitehead
Funding Agency and Grant Number	Funding Agency Grant Number National Institute of Diabetes and Digestive and Kidney Disease R01 DK031369
Corresponding Author	Giuseppe Chiarioni, MD, Division of Gastroenterology of the University of Verona, Valeggio s/M Hospital, Azienda Ospedaliera Universitaria Integrata di Verona, 37067 Valeggio sul Mincio, Verona, Italy. chiarioni@tin.it
Key Words	Fecal incontinence; Neuromodulation; Sacral nerve stimulation; Biofeedback; Anal sphincter
Core Tip	This review summarizes the evidence for neuromodulation of fecal incontinence. Neuromodulation is effective for some patients with fecal incontinence of different etiology unknown mechanism; when analyzed by intent to treat analysis, the median responder rate is 59%. The most common serious adverse event is infection at the site of implant which occurs in about 3% of patients. Cost of treatment is high relative to conservative treatment and biofeedback but seems to be cost-effective when offset by gains in quality-adjusted years. Randomized controlled trials comparing neuromodulation with biofeedback therapy in fecal incontinence are advisable to tailor patients' management.
Publish Date	2013-11-16 18:29
Citation	Chiarioni G, Palsson OS, Asteria CR, Whitehead WE. Neuromodulation for fecal incontinence: An effective surgical intervention. World J Gastroenterol 2013; 19(41): 7048-7054
URL	http://www.wjgnet.com/1007-9327/full/v19/i41/7048.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i41.7048

Full Article (PDF)	WJG-19-7048.pdf
Manuscript File	4356-Review.docx
Answering Reviewers	4356-Answering reviewers.pdf
Copyright License Agreement	4356-Copyright assignment.pdf
Peer-review Report	4356-Peer review(s).pdf
Scientific Editor Work List	4356-Scientific editor work list.doc