Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	4361
Country	Italy

Received	2013-06-28 10:46
Peer-Review Started	2013-06-28 16:38
To Make the First Decision	2013-08-08 11:11
Return for Revision	2013-08-19 20:02
Revised	2013-09-09 19:51
Second Decision	2013-10-16 11:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-16 12:07
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-25 15:58
Publish the Manuscript Online	2013-11-15 10:10

ISSN	2150-5330 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biology
Manuscript Type	Minireviews
Article Title	Fibrogenesis and fibrosis in inflammatory bowel diseases: Good and bad side of same coin?
Manuscript Source	Invited Manuscript
All Author List	Mariabeatrice Principi, Floriana Giorgio, Giuseppe Losurdo, Viviana Neve, Antonella Contaldo, Alfredo Di Leo and Enzo Ierardi
Funding Agency and Grant Number
Corresponding Author	Enzo Ierardi, Professor, Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy. enzo.ierardi@fastwebnet.it
Key Words	Fibrogenesis; Fibrosis; Tumor necrosis factor -; Syndecan 1; Basic fibroblast growth factor; Cellular fibrogenic phenotype; Inflammatory bowel diseases
Core Tip	The present minireview reports an outline of the mechanisms of fibrogenesis in inflammatory bowel diseases. Potential fibrogenetic cells and their characterization are detailed. Recent advances in possible molecular mechanisms are highlighted. Our experience, suggesting the hypothesis of a possible molecular mechanism of mucosal healing, is described. The modalities whereby a deregulation of this molecular pattern may lead to fibrotic strictures in Crohn’s disease are also illustrated. Finally, possible clinical implications are outlined.
Publish Date	2013-11-15 10:10
Citation	Principi M, Giorgio F, Losurdo G, Neve V, Contaldo A, Di Leo A, Ierardi E. Fibrogenesis and fibrosis in inflammatory bowel diseases: Good and bad side of same coin? World J Gastrointest Pathophysiol 2013; 4(4): 100-107
URL	http://www.wjgnet.com/2150-5330/full/v4/i4/100.htm
DOI	http://dx.doi.org/10.4291/wjgp.v4.i4.100

Full Article (PDF)	WJGP-4-100.pdf
Manuscript File	4361-Review.doc
Answering Reviewers	4361-Answering reviewers.pdf
Copyright License Agreement	4361-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Fibrogenesis and inflammatory bowel diseases.doc
Non-Native Speakers of English Editing Certificate	4361-Language certificate.pdf
Peer-review Report	4361-Peer reviewer(s).pdf
Scientific Editor Work List	4361-Scientific editor work list.doc