Publication Name	World Journal of Gastroenterology
Manuscript ID	4363
Country	Italy

Received	2013-06-28 10:55
Peer-Review Started	2013-06-28 16:57
To Make the First Decision	2013-07-26 18:30
Return for Revision	2013-08-06 09:57
Revised	2013-08-06 17:33
Second Decision	2013-09-16 17:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 06:17
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-08 08:54
Publish the Manuscript Online	2013-11-16 18:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	PNPLA3 I148M polymorphism and progressive liver disease
Manuscript Source	Invited Manuscript
All Author List	Paola Dongiovanni, Benedetta Donati, Roberta Fares, Rosa Lombardi, Rosellina Margherita Mancina, Stefano Romeo and Luca Valenti
Funding Agency and Grant Number	Funding Agency Grant Number Associazione Malattie Metaboliche del Fegato ONLUS (Non-profit organization for the Study and Care of Metabolic Liver Diseases) Centro Studi Malattie Metaboliche del Fegato, Università degli Studi di Milano
Corresponding Author	Luca Valenti, MD, Assistant Professor, Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Department of Pathophysiology and Transplantation, Universit?degli Studi di Milano, Pad. Granelli, via F Sforza 35, 20122 Milano, Italy. luca.valenti@unimi.it
Key Words	Alcoholic liver disease; Chronic hepatitis C virus hepatitis; Fibrogenesis; Genetics; Hepatocellular carcinoma; Liver disease; Nonalcoholic fatty liver disease; Patatin-like phospholipase domain-containing 3; Single nucleotide polymorphism; Steatosis
Core Tip	The 148 Isoleucine to Methionine protein variant (I148M) of patatin-like phospholipase domain-containing 3 (PNPLA3) has recently been identified as a major determinant of liver fat content. Several studies conducted in different ethnicities confirmed that I148M influences the full spectrum of liver damage: from simple steatosis to nonalcoholic steatohepatitis and progressive fibrosis to hepatocellular carcinoma. Furthermore, I148M turned out to represent a major determinant of progression of alcohol related steatohepatitis, and to influence fibrosis progression and related clinical outcomes in chronic hepatitis C virus hepatitis, as well as other in liver diseases. All in all, studies suggest that the PNPLA3 I148M polymorphism may represent a general modifier of fibrogenesis in liver diseases.
Publish Date	2013-11-16 18:29
Citation	Dongiovanni P, Donati B, Fares R, Lombardi R, Mancina RM, Romeo S, Valenti L. PNPLA3 I148M polymorphism and progressive liver disease. World J Gastroenterol 2013; 19(41): 6969-6978
URL	http://www.wjgnet.com/1007-9327/full/v19/i41/6969.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i41.6969

Full Article (PDF)	WJG-19-6969.pdf
Manuscript File	4363-Review.doc
Answering Reviewers	4363-Answering reviewers.pdf
Copyright License Agreement	4363-Copyright assignment.pdf
Peer-review Report	4363-Peer reviewer(s).pdf
Scientific Editor Work List	4363-Scientific editor work list.doc