Publication Name	World Journal of Radiology
Manuscript ID	4366
Country	Italy

Received	2013-06-28 11:15
Peer-Review Started	2013-06-28 17:13
To Make the First Decision	2013-08-08 11:10
Return for Revision	2013-08-13 11:02
Revised	2013-09-06 23:54
Second Decision	2013-10-18 10:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-10-18 11:50
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-04 09:39
Publish the Manuscript Online	2013-11-28 15:57

ISSN	1949-8470 (online)
Open Access
Copyright
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Category	Engineering, Biomedical
Manuscript Type	Autobiography
Article Title	Magnetically-coated silica nanospheres for dual-mode imaging at low ultrasound frequency
Manuscript Source	Invited Manuscript
All Author List	Fernanda Chiriacò, Giulia Soloperto, Antonio Greco, Francesco Conversano, Andrea Ragusa, Luca Menichetti and Sergio Casciaro
Funding Agency and Grant Number	Funding Agency Grant Number Italian Ministry of Instruction and Research ESR PO Apulia Region 2007-2013-Action 1.2.4 3Q5AX31 Progetto Bandiera NANOMAX ENCODER
Corresponding Author	Dr. Sergio Casciaro, Consiglio Nazionale delle Ricerche, Istituto di Fisiologia Clinica (CNR-IFC) c/o Campus Ecotekne, via per Monteroni, 73100 Lecce, Italy. sergio.casciaro@cnr.it
Key Words	Ultrasound; Magnetic resonance; Nanocomposite; Dual-mode Imaging; Contrast agent; Diagnostic imaging
Core Tip	In this work we investigated the acoustic response of novel dual-mode nanoparticle contrast agents, detectable through both ultrasound (US) and magnetic resonance imaging (MRI), made of silica nanospheres (SiNSs) of different diameters coated with superparamagnetic nanoparticles [iron-oxide (IO) or FePt-IO nanocrystals]. Magnetically-coated SiNSs were insonified with US pulses in the lower diagnostic range (2.5-4.5 MHz), which are commonly employed for the imaging of deep organs, and the results were compared with those of pure SiNSs. The US characterization of these nanocomposites shows that FePt-IO, rather than IO, was the best magnetic coating for realizing nanosized contrast agents suitable for dual mode imaging of deep targets, combining US and MRI techniques.
Publish Date	2013-11-28 15:57
Citation	Chiriacò F, Soloperto G, Greco A, Conversano F, Ragusa A, Menichetti L, Casciaro S. Magnetically-coated silica nanospheres for dual-mode imaging at low ultrasound frequency. World J Radiol 2013; 5(11): 411-420
URL	http://www.wjgnet.com/1949-8470/full/v5/i11/411.htm
DOI	http://dx.doi.org/10.4329/wjr.v5.i11.411

Full Article (PDF)	WJR-5-411.pdf
Manuscript File	4366-Review.doc
Answering Reviewers	4366-Answering reviewers.pdf
Copyright License Agreement	4366-Copyright assignment.pdf
Peer-review Report	4366-Peer review(s).pdf
Scientific Editor Work List	4366-Scientific editor work list.doc