Publication Name	World Journal of Gastroenterology
Manuscript ID	4378
Country	Italy

Received	2013-06-28 12:13
Peer-Review Started	2013-06-28 18:32
To Make the First Decision	2013-07-05 18:34
Return for Revision	2013-07-08 14:26
Revised	2013-07-27 01:02
Second Decision	2013-08-16 19:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-17 00:06
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-25 14:43
Publish the Manuscript Online	2013-11-16 18:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Are metabolic factors still important in the era of direct antiviral agents in patients with chronic hepatitis C?
Manuscript Source	Invited Manuscript
All Author List	Alessandro Grasso, Federica Malfatti and Roberto Testa
Funding Agency and Grant Number
Corresponding Author	Alessandro Grasso, MD, Gastroenterology Unit, Department of Internal Medicine, San Paolo Hospital, Via Genova 38, 17100 Savona, Italy. a.grasso@asl2.liguria.it
Key Words	Metabolic factors; Insulin resistance; Direct antiviral agents; Chronic hepatitis C
Core Tip	This editorial explores the past and present role of metabolic factors by analyzing the data that has emerged from the post hoc analysis of registrative trials of direct antiviral-based treatment. Low-density lipoprotein-cholesterol and statin use proved to be predictors of sustained viral response (SVR) in both boceprevir and telaprevir-treated patients, respectively. Furthermore, HOMA-IR negatively influenced SVR in prior partial and null responders treated with telaprevir-based schedules. By transferring these data to the real world scenario in which patients have comorbidities, advanced fibrosis and prior failure to antiviral treatment, we believe that metabolic factors might play a non-negligible role in influencing antiviral response, even in triple therapy.
Publish Date	2013-11-16 18:29
Citation	Grasso A, Malfatti F, Testa R. Are metabolic factors still important in the era of direct antiviral agents in patients with chronic hepatitis C? World J Gastroenterol 2013; 19(41): 6947-6956
URL	http://www.wjgnet.com/1007-9327/full/v19/i41/6947.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i41.6947

Full Article (PDF)	WJG-19-6947.pdf
Manuscript File	4378-Review.docx
Answering Reviewers	4378-Answering reviewers.pdf
Copyright License Agreement	4378-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	4378-Language certificate.pdf
Peer-review Report	4378-Peer review(s).pdf
Scientific Editor Work List	4378-Scientific editor work list.doc