Publication Name	World Journal of Pharmacology
Manuscript ID	4388
Country	Australia

Received	2013-06-28 17:10
Peer-Review Started	2013-06-28 19:34
To Make the First Decision	2013-08-21 18:34
Return for Revision	2013-08-23 09:25
Revised	2013-09-17 12:02
Second Decision	2013-10-18 10:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-18 11:52
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-29 16:35
Publish the Manuscript Online	2013-12-18 16:32

ISSN	2220-3192 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Autobiography
Article Title	Inhibitory effects of apigenin and kaempferol on the essential solute carrier transporters
Manuscript Source	Invited Manuscript
All Author List	Ting Chan, Zhen Li, Jian Zheng, Florence Shin Gee Cheung, Ling Zhu and Fanfan Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Faculty of Pharmacy, the University of Sydney, Australia
Corresponding Author	Fanfan Zhou, PhD, Faculty of Pharmacy, University of Sydney, City Road, Darlington, NSW 2006, Australia. fanfan.zhou@sydney.edu.au
Key Words	Apigenin; Kaempferol; Organic anion transporters; Organic cation transporters; Pharmacokinetics; Drug-drug/herb interactions
Core Tip	Our study showed that both apigenin and kaempferol could significantly inhibit various solute carrier transporters, in particular organic anion transporter 3, at their clinical doses. Inhibition on these transporters can greatly impact on pharmacokinetic performance of drugs that are substrates of these transporters by altering their absorption, distribution and excretion. Precautions should be implemented when co-administering apigenin and kaempferol with drugs that are substrates of these specific solute carrier transporters, in order to maximise desired therapeutic outcomes and avoid unexpected toxicities. This overall enhances our understanding of drug-drug/herb interactions related to apigenin and kaempferol and provides critical information to improve future multi-drug therapies.
Publish Date	2013-12-18 16:32
Citation	Chan T, Li Z, Zheng J, Cheung FSG, Zhu L, Zhou F. Inhibitory effects of apigenin and kaempferol on the essential solute carrier transporters. World J Pharmacol 2013; 2(4): 115-121
URL	http://www.wjgnet.com/2220-3192/full/v2/i4/115.htm
DOI	http://dx.doi.org/10.5497/wjp.v2.i4.115

Full Article (PDF)	WJP-2-115.pdf
Full Article (Word)	WJP-2-115.doc
Manuscript File	4388-Review.doc
Answering Reviewers	4388-Answering reviewers.pdf
Copyright License Agreement	4388-Copyright assignment.pdf
Peer-review Report	4388-Peer review(s).pdf
Scientific Editor Work List	4388-Scientific editor work list.doc