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Publication Name World Journal of Pharmacology
Manuscript ID 4388
Country/Territory Australia
Received
2013-06-28 17:10
Peer-Review Started
2013-06-28 19:34
To Make the First Decision
2013-08-21 18:34
Return for Revision
2013-08-23 09:25
Revised
2013-09-17 12:02
Second Decision
2013-10-18 10:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-10-18 11:52
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-10-29 16:35
Publish the Manuscript Online
2013-12-18 16:32
ISSN 2220-3192 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pharmacology & Pharmacy
Manuscript Type Autobiography
Article Title Inhibitory effects of apigenin and kaempferol on the essential solute carrier transporters
Manuscript Source Invited Manuscript
All Author List Ting Chan, Zhen Li, Jian Zheng, Florence Shin Gee Cheung, Ling Zhu and Fanfan Zhou
Funding Agency and Grant Number
Funding Agency Grant Number
Faculty of Pharmacy, the University of Sydney, Australia
Corresponding Author Fanfan Zhou, PhD, Faculty of Pharmacy, University of Sydney, City Road, Darlington, NSW 2006, Australia. fanfan.zhou@sydney.edu.au
Key Words Apigenin; Kaempferol; Organic anion transporters; Organic cation transporters; Pharmacokinetics; Drug-drug/herb interactions
Core Tip Our study showed that both apigenin and kaempferol could significantly inhibit various solute carrier transporters, in particular organic anion transporter 3, at their clinical doses. Inhibition on these transporters can greatly impact on pharmacokinetic performance of drugs that are substrates of these transporters by altering their absorption, distribution and excretion. Precautions should be implemented when co-administering apigenin and kaempferol with drugs that are substrates of these specific solute carrier transporters, in order to maximise desired therapeutic outcomes and avoid unexpected toxicities. This overall enhances our understanding of drug-drug/herb interactions related to apigenin and kaempferol and provides critical information to improve future multi-drug therapies.
Publish Date 2013-12-18 16:32
Citation Chan T, Li Z, Zheng J, Cheung FSG, Zhu L, Zhou F. Inhibitory effects of apigenin and kaempferol on the essential solute carrier transporters. World J Pharmacol 2013; 2(4): 115-121
URL http://www.wjgnet.com/2220-3192/full/v2/i4/115.htm
DOI http://dx.doi.org/10.5497/wjp.v2.i4.115
Full Article (PDF) WJP-2-115.pdf
Full Article (Word) WJP-2-115.doc
Manuscript File 4388-Review.doc
Answering Reviewers 4388-Answering reviewers.pdf
Copyright License Agreement 4388-Copyright assignment.pdf
Peer-review Report 4388-Peer review(s).pdf
Scientific Editor Work List 4388-Scientific editor work list.doc