Publication Name	World Journal of Gastroenterology
Manuscript ID	4397
Country	Spain

Received	2013-06-28 18:28
Peer-Review Started	2013-06-28 22:23
To Make the First Decision	2013-07-19 08:36
Return for Revision	2013-07-21 00:02
Revised	2013-07-23 21:43
Second Decision	2013-09-16 17:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 06:20
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-10-02 20:26
Typeset the Manuscript	2013-10-25 14:28
Publish the Manuscript Online	2013-11-16 18:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Review
Article Title	Quasispecies structure, cornerstone of hepatitis B virus infection: Mass sequencing approach
Manuscript Source	Invited Manuscript
All Author List	Francisco Rodriguez-Frias, Maria Buti, David Tabernero and Maria Homs
Funding Agency and Grant Number	Funding Agency Grant Number Instituto de Salud Carlos III PI12/1893 European Regional Development Fund (ERDF) Instituto Carlos III of the Spanish Ministry of Health Consumer Affairs
Corresponding Author	Francisco Rodriguez-Frias, PhD, Proteins, Hepatitis and Molecular Genetics Unit, Department of Biochemistry, Vall d'Hebron Hospital, Autonomous University of Barcelona, Paseo Vall d'Hebron 19-129, 08035 Barcelona, Spain. frarodri@vhebron.net
Key Words	Hepatitis B virus; Next generation sequencing; Quasispecies; Linkage analysis; Gene overlapping
Core Tip	We provide an update of hepatitis B virus (HBV) virology, focusing on its complex replication cycle which generates high genetic variability, which led HBV infection to evolve as viral quasispecies, complex distributions of variant populations that are closely related but not identical. We also discuss the clinical and virological implications of this population structure and the application of different next-generation sequencing approaches, which enable analysis of thousands of clonally amplified regions, to study these heterogeneous viral populations.
Publish Date	2013-11-16 18:29
Citation	Rodriguez-Frias F, Buti M, Tabernero D, Homs M. Quasispecies structure, cornerstone of hepatitis B virus infection: Mass sequencing approach. World J Gastroenterol 2013; 19(41): 6995-7023
URL	http://www.wjgnet.com/1007-9327/full/v19/i41/6995.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i41.6995

Full Article (PDF)	WJG-19-6995.pdf
Manuscript File	4397-Review.doc
Answering Reviewers	4397-Answering reviewers.pdf
Copyright License Agreement	4397-Copyright assignment.doc
Peer-review Report	4397-Peer review(s).pdf
Scientific Editor Work List	4397-Scientific editor work list.doc