Publication Name	World Journal of Pharmacology
Manuscript ID	44515
Country	United Arab Emirates

Received	2018-11-14 03:51
Peer-Review Started	2018-11-14 09:26
To Make the First Decision	2018-12-10 00:23
Return for Revision	2018-12-18 06:14
Revised	2019-01-20 07:38
Second Decision	2019-01-26 09:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-01-28 20:42
Articles in Press	2019-01-28 20:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-01-29 08:41
Publish the Manuscript Online	2019-01-30 05:42

ISSN	2220-3192 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Pharmacology & Pharmacy
Manuscript Type	Review
Article Title	Tobacco smoking and its drug interactions with comedications involving CYP and UGT enzymes and nicotine
Manuscript Source	Unsolicited Manuscript
All Author List	Naina Mohamed Pakkir Maideen
ORCID	Author(s) ORCID Number Naina Mohamed Pakkir Maideen http://orcid.org/0000-0002-6950-9783
Funding Agency and Grant Number
Corresponding Author	Naina Mohamed Pakkir Maideen, PhD, Pharmacist, Department of Pharmacy, Dubai Health Authority, Al Maktoum Bridge Street, Dubai 4545, United Arab Emirates. nmmaideen@dha.gov.ae
Key Words	Drug Interactions; Tobacco Smoking; Cytochrome P450 enzymes; Uridine diphosphate-glucuronosyltransferases enzymes; Nicotine
Core Tip	Use of medications among smokers is more common, nowadays. This review is aimed to identify the medications affected by smoking, involving cytochrome P450 (CYP) and uridine diphosphate-glucuronosyltransferases (UGTs) enzymes and Nicotine. The drugs metabolized by CYP1A1, CYP1A2, CYP2E1 and UGT enzymes might be affected by tobacco smoking and the smokers taking medications metabolized by those enzymes, may need higher doses due to decreased plasma concentrations through accelerated metabolism by Polycyclic aromatic hydrocarbons of tobacco smoke. The prescribers and the pharmacists are required to be aware of medications affected by tobacco smoking to prevent the toxicity-associated complications during smoking cessation.
Publish Date	2019-01-30 05:42
Citation	Maideen NMP. Tobacco smoking and its drug interactions with comedications involving CYP and UGT enzymes and nicotine. World J Pharmacol 2019; 8(2): 14-25
URL	https://www.wjgnet.com/2220-3192/full/v8/i2/14.htm
DOI	https://dx.doi.org/10.5497/wjp.v8.i2.14

Full Article (PDF)	WJP-8-14.pdf
Full Article (Word)	WJP-8-14.docx
Manuscript File	44515-Review.docx
Answering Reviewers	44515-Answering reviewers.pdf
Audio Core Tip	44515-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	44515-Conflict-of-interest statement.pdf
Copyright License Agreement	44515-Copyright license agreement.pdf
Peer-review Report	44515-Peer-review(s).pdf
Scientific Editor Work List	44515-Scientific editor work list.pdf