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Articles Published Processes
3/28/2019 9:14:40 AM | Browse: 920 | Download: 1557
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Received |
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2018-11-27 01:14 |
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Peer-Review Started |
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2018-11-27 03:14 |
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To Make the First Decision |
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2019-01-11 06:30 |
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Return for Revision |
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2019-01-11 07:44 |
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Revised |
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2019-01-29 07:33 |
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Second Decision |
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2019-01-30 08:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-01-30 18:27 |
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Articles in Press |
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2019-01-30 18:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-02-06 03:10 |
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Typeset the Manuscript |
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2019-03-21 08:25 |
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Publish the Manuscript Online |
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2019-03-28 09:14 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Hu, Wei Hong, Kan-Nan Yao, Xiao-Hong Zhu, Zhi-Yun Chen and Lei Ye |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Zhejiang province China |
LQ19H290001 |
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| Corresponding Author |
Lei Ye, MAMS, Doctor, Doctor, Department of Infectious Disease, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 YouDian Road, Hangzhou 310006, Zhejiang Province, China. huj520@163.com |
| Key Words |
Ursodeoxycholic acid; Hepatic lipid metabolism; AKT/mTOR/SREBP-1; Hepatic steatosis |
| Core Tip |
Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease. Many studies show that the disorder of hepatic lipid metabolism is major pathogenesis. Increased evidence indicates AKT/mTOR/SREBP-1 signaling pathway is a key pathway to regulate hepatocellular lipid metabolism. At present, there are few studies on the mechanism of NAFLD in hepatic lipid metabolism. We aimed to investigate the functional mechanism of ursodeoxycholic acid (UDCA) in oleic acid induced cellular models of NAFLD. The possible molecular mechanism and related targets of regulating hepatic lipid metabolism were explored, and the correlation between the occurrence of NAFLD and AKT/mTOR/SREBP-1 signaling pathway was explored. We provided more sufficient experimental basis for clinical application of UDCA in the treatment of NAFLD. |
| Publish Date |
2019-03-28 09:14 |
| Citation |
Hu J, Hong W, Yao KN, Zhu XH, Chen ZY, Ye L. Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway. World J Gastroenterol 2019; 25(12):1492-1501 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i12/1492.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i12.1492 |
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