Publication Name	World Journal of Gastroenterology
Manuscript ID	4464
Country	Japan

Received	2013-07-01 10:32
Peer-Review Started	2013-07-02 09:07
To Make the First Decision	2013-08-08 11:33
Return for Revision	2013-08-08 16:01
Revised	2013-08-24 12:11
Second Decision	2013-09-03 14:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-04 07:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-15 17:18
Publish the Manuscript Online	2013-11-13 08:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Effects of probiotics on nonalcoholic fatty liver disease: A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Yan-Yan Ma, Lin Li, Chao-Hui Yu, Zhe Shen, Li-Hua Chen and You-Ming Li
Funding Agency and Grant Number
Corresponding Author	You-Ming Li, MD, Department of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zlym@zju.edu.cn
Key Words	Probiotics; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Liver function; Insulin resistance; Meta-analysis
Core Tip	For many decades, researchers have carried out studies on the treatment of nonalcoholic fatty liver disease (NAFLD). However, no firm conclusions have been made regarding the efficacy of various treatments for NAFLD. Here we conducted a meta-analysis of the pooled data from randomized controlled trials to assess the efficacy of probiotic therapies and showed that probiotic therapy signi铿乧antly decreased alanine aminotransferase, aspartate transaminase, total-cholesterol, high density lipoprotein, tumor necrosis factor-飦?and homeostasis model assessment of insulin resistance. Thus, probiotics may help to improve liver function, fat metabolism and insulin resistance in NAFLD patients.
Publish Date	2013-11-13 08:37
Citation	Shimoyama S. Diabetes mellitus carries a risk of gastric cancer: A meta-analysis. World J Gastroenterol 2013; 19(40): 6902-6910
URL	http://www.wjgnet.com/1007-9327/full/v19/i40/6902.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i40.6902

Manuscript File	4464-Review.doc
Answering Reviewers	4464-Answering reviewers.pdf
Copyright License Agreement	4464-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4464-Language certificate.pdf
Peer-review Report	4464-Peer review(s).pdf
Scientific Editor Work List	4464-Scientific editor work list.doc