Publication Name	World Journal of Gastroenterology
Manuscript ID	4466
Country	China

Received	2013-07-01 10:40
Peer-Review Started	2013-07-01 13:22
To Make the First Decision	2013-07-30 17:18
Return for Revision	2013-07-31 09:39
Revised	2013-08-10 21:03
Second Decision	2013-08-16 19:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-08-17 00:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-09-10 11:29
Typeset the Manuscript	2013-09-19 10:03
Publish the Manuscript Online	2013-10-18 17:02

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Cytokeratin 8 is increased in hepatitis C virus cells and its ectopic expression induces apoptosis of SMMC7721 cells
Manuscript Source	Invited Manuscript
All Author List	Ming-Zhu Sun, Shuang-Suo Dang, Wen-Jun Wang, Xiao-Li Jia, Song Zhai, Xin Zhang, Mei Li, Ya-Ping Li and Meng Xun
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81170393
Corresponding Author	Shuang-Suo Dang, PhD, Professor, Director of Department of Infectious Diseases, the Second Affiliated Hospital of College of Medicine, Xi'an Jiaotong University, No. 157, Xi Wu Road, Xi'an 710004, Shaanxi Province, China. dang212@126.com
Key Words	Hepatitis C virus cell culture system; Cytokeratin 8; Up-regulation; Eukaryotic expression; Apoptosis
Core Tip	In this study, we observed that cytokeratin 8 (CK8) levels are elevated in hepatitis C virus (HCV) cell culture system and its ectopic expression decreased the proliferation and induced apoptosis of SMMC7721 cells. CK8 up-regulation might have a functional role in HCV infection and pathogenesis, and could be a promising target for the treatment of HCV infection.
Publish Date	2013-10-18 17:02
Citation	Sun MZ, Dang SS, Wang WJ, Jia XL, Zhai S, Zhang X, Li M, Li YP, Xun M. Cytokeratin 8 is increased in hepatitis C virus cells and its ectopic expression induces apoptosis of SMMC7721 cells. World J Gastroenterol 2013; 19(37): 6178-6187
URL	http://www.wjgnet.com/1007-9327/full/v19/i37/6178.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i37.6178

Full Article (PDF)	WJG-19-6178.pdf
Manuscript File	4466-Review.docx
Answering Reviewers	4466-Answering reviewers.pdf
Copyright License Agreement	4466-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4466-Language certificate.pdf
Peer-review Report	4466-Peer review(s).pdf
Scientific Editor Work List	4466-Scientific editor work list.doc