Publication Name	World Journal of Gastroenterology
Manuscript ID	4468
Country	China

Received	2013-07-01 11:01
Peer-Review Started	2013-07-01 13:31
To Make the First Decision	2013-07-30 17:18
Return for Revision	2013-07-31 09:44
Revised
Second Decision	2013-09-16 17:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 06:40
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-15 13:42
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Identification of Annexin A1 protein expression in human gastric adenocarcinoma using proteomics and tissue microarray
Manuscript Source	Invited Manuscript
All Author List	Zhi-Qiang Zhang, Xiu-Juan Li, Gui-Tao Liu, Yu Xia, Xiang-Yang Zhang and Hao Wen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81001101 Natural Science Foundation of Xinjiang Uygur Autonomous Region, China 2010211B20
Corresponding Author	Hao Wen, Professor, Department of Liver and Laparoscopic Surgery, Digestive and Vascular Centre, the First Affiliated Hospital, Xinjiang Medical University, No. 137 Liyushan South Road, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China. zhangzhiqiang011@126.com
Key Words	Gastric cancer; Annexin A1 protein; Proteomics; Tissue microarray; Immunohistochemistry
Core Tip	The anti-inflammatory protein Annexin A1 (ANXA1) mediates various important physiological and pathophysiological processes. Evidence has shown that ANXA1 is related to the development and progression of human multi-tumours. However, the ANXA1 expression in gastric adenocarcinoma of Chinese patients and the relationship between this protein and its clinicopathological parameters remain unclear. In the present study, the ANXA1 expression in gastric adenocarcinoma of Chinese patients was investigated by proteomics and western blot analysis. Authors examined 75 pairs of gastric adenocarcinoma and paracarcinoma tissues by tissue microarray to determine the presence of ANXA1 by immunohistochemistry. They found that ANXA1 expression was upregulated and involved in human gastric adenocarcinoma invasion and metastasis. Our findings suggested that ANXA1 might be used as a valuable biomarker in clinical diagnosis, prognostic prediction and targeted therapy of gastric cancer.
Publish Date	2013-12-18 09:53
Citation	Zhang ZQ, Li XJ, Liu GT, Ping Y, Xia Y, Wen H. Identification of Annexin A1 protein expression in human gastric adenocarcinoma using proteomics and tissue microarray. World J Gastroenterol 2013; 19(43): 7795-7803
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7795.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7795

Full Article (PDF)	WJG-19-7795.pdf
Manuscript File	4468-Review.doc
Answering Reviewers	4468-Answering reviewers.pdf
Copyright License Agreement	4468-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4468-Language certificate.pdf
Peer-review Report	4468-Peer review(s).pdf
Scientific Editor Work List	4468-Scientific editor work list.doc