Publication Name	World Journal of Gastroenterology
Manuscript ID	4471
Country	China

Received	2013-07-01 11:39
Peer-Review Started	2013-07-02 10:10
To Make the First Decision	2013-08-21 18:37
Return for Revision	2013-08-22 19:25
Revised	2013-08-28 21:56
Second Decision	2013-09-16 17:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-17 06:41
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-26 10:25
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Amelioration of carbon tetrachloride-induced cirrhosis and portal hypertension in rat using adenoviral gene transfer of Akt
Manuscript Source	Invited Manuscript
All Author List	Gang Deng, Xiang-Jun Huang, Hong-Wu Luo, Fei-Zhou Huang, Xun-Yang Liu and Yong-Heng Wang
Funding Agency and Grant Number
Corresponding Author	Hong-Wu Luo, MD, Department of Hepatobiliary and Pancreatic Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China. luohongwuzny@sina.com
Key Words	Adenovirus; Akt; Gene transfer; Apoptosis; Cirrhosis; Carbon tetrachloride; Rat
Core Tip	In the present study, we have demonstrated for the first time that Ad-myr-HA-Akt virus was a useful tool to prevent carbon tetrachloride-induced cirrhosis in rat model. Our data obtained at different levels, from function to histological changes, apoptosis rate of hepatocytes, activation of hepatic stellate cells, deposition of collagen, portal vein pressure and NO level, which were all consistently and collectively supported the hypothesis that introduction of Ad-myr-HA-Akt virus inhibits the development of cirrhosis.
Publish Date	2013-12-18 09:53
Citation	Deng G, Huang XJ, Luo HW, Huang FZ, Liu XY, Wang YH. Amelioration of carbon tetrachloride-induced cirrhosis and portal hypertension in rat using adenoviral gene transfer of Akt. World J Gastroenterol 2013; 19(43): 7778-7787
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7778.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7778

Full Article (PDF)	WJG-19-7778.pdf
Manuscript File	4471-Review.doc
Answering Reviewers	4471-Answering reviewers.pdf
Copyright License Agreement	4471-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4471-Language certificate.pdf
Peer-review Report	4471-Peer review(s).pdf
Scientific Editor Work List	4471-Scientific editor work list.doc