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Articles Published Processes
3/22/2019 11:26:49 AM | Browse: 1434 | Download: 2603
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Received |
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2018-12-06 00:19 |
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Peer-Review Started |
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2018-12-06 09:28 |
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To Make the First Decision |
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2019-01-02 01:06 |
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Return for Revision |
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2019-01-10 11:00 |
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Revised |
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2019-01-16 22:20 |
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Second Decision |
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2019-01-30 08:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-01-30 19:33 |
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Articles in Press |
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2019-01-30 19:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-03-22 06:53 |
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Publish the Manuscript Online |
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2019-03-22 11:26 |
| ISSN |
2218-4333 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Eva Wimmer, Stephan Ihrler, Olivier Gires, Sylvia Streit, Wolfgang Issing and Christoph Bergmann |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Christoph Bergmann, MD, PhD, Assistant Professor, Senior Lecturer, Surgeon, Department of Otorhinolaryngology, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany. christoph.bergmann@uk-essen.de |
| Key Words |
Fibroblast growth factor receptor 4; Single-nucleotide polymorphism; Head and neck squamous cell carcinoma; Reduced survival; Cancer progression; Polymerase chain reaction; Immunohistochemistry; Outcome |
| Core Tip |
Single-nucleotide polymorphism Arg388 of the fibroblast growth factor receptor-4 (FGFR4) is associated with a reduced overall survival in patients with various cancers. Here, the potential clinical significance of FGFR4 Arg388 was investigated in the context of head and neck carcinoma in 284 patients using immunohistochemistry and polymerase chain reaction. Advanced tumor stage and local metastasis was significantly associated with reduced disease-free survival in mutant FGFR4 Arg388 carriers. Increased expression of FGFR4 correlated significantly with worse overall survival impacting tumor progression in patients with head and neck squamous cell carcinoma and may present a useful target within a multimodal therapeutic interven-tion. |
| Publish Date |
2019-03-22 11:26 |
| Citation |
Wimmer E, Ihrler S, Gieres O, Streit S, Issing W, Bergmann C. Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas. World J Clin Oncol 2019; 10(3): 136-148 |
| URL |
https://www.wjgnet.com/2218-4333/full/v10/i3/136.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v10.i3.136 |
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