Publication Name	World Journal of Hepatology
Manuscript ID	4481
Country	Japan

Received	2013-07-02 08:57
Peer-Review Started	2013-07-02 15:06
To Make the First Decision	2013-07-26 18:41
Return for Revision	2013-08-06 10:22
Revised	2013-08-28 06:19
Second Decision	2013-10-16 11:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-10-16 12:09
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-23 18:33
Publish the Manuscript Online	2013-10-25 08:47

ISSN	1948-5182 (online)
Open Access
Copyright
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot “Prunus mume”
Manuscript Source	Invited Manuscript
All Author List	Takashi Hoshino, Hitoshi Takagi, Atsushi Naganuma, Eri Koitabashi, Sanae Uehara, Naomi Sakamoto, Tomohiro Kudo, Ken Sato and Satoru Kakizaki
Funding Agency and Grant Number
Corresponding Author	Hitoshi Takagi, MD, PhD, Department of Gastroenterology, Takasaki General Center Hospital, 36 Takamatsu-machi, Takasaki, Gunma 370-0829, Japan. htakagi@takasaki-hosp.jp
Key Words	MK615; Hepatocellular carcinoma; Japanese apricot; Prunus mume
Core Tip	We experienced a case with advanced hepatocellular carcinoma (HCC) for which MK615, a compound extracted from the Japanese apricot “Prunus mume” was effective against both lymph node and pulmonary metastases. MK615 was administered as a final alternative therapy. Three months later, her alpha-fetoprotein level decrease and both the lymph node and pulmonary metastases decreased in size. MK615 has been reported to have in vitro anti-tumor activities against several cancer cell lines, including HCC. Although further investigations are necessary to clarify its safety and efficacy in humans, MK615 may be useful for the treatment of HCC, without serious adverse effects.
Publish Date	2013-10-25 08:47
Citation	Hoshino T, Takagi H, Naganuma A, Koitabashi E, Uehara S, Sakamoto N, Kudo T, Sato K, Kakizaki S. Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot “Prunus mume”. World J Hepatol 2013; 5(10): 596-600
URL	http://www.wjgnet.com/1948-5182/full/v5/i10/596.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i10.596

Full Article (PDF)	WJH-5-596.pdf
Manuscript File	4481-Review.docx
Answering Reviewers	4481-Answering reviewers.pdf
Copyright License Agreement	4481-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4481-Language certificate.pdf
Peer-review Report	4481-Peer reviewer(s).pdf
Scientific Editor Work List	4481-Scientific editor work list.doc