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Articles Published Processes
9/1/2014 2:51:00 PM | Browse: 1318 | Download: 1461
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Received |
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2013-07-02 09:46 |
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Peer-Review Started |
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2013-07-02 15:45 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2013-11-04 15:57 |
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Revised |
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2013-11-10 18:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-01-06 17:20 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-01-06 19:11 |
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Articles in Press |
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Edit the Manuscript by Language Editor |
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2014-02-17 17:48 |
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Typeset the Manuscript |
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2014-03-04 11:03 |
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Publish the Manuscript Online |
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2014-03-18 14:14 |
| Category |
Pathology |
| Manuscript Type |
Autobiography |
| Article Title |
Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sang Hwa Lee, Sung-Im Do and Hyun-Soo Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Aerospace Medicine Research Project funded by the Medical Division, Headquarter, Republic of Korea Air Force (2012) |
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| Corresponding Author |
Hyun-Soo Kim, MD, Department of Pathology, Aerospace Medicine Research Center, Aerospace Medical Center, Republic of Korea Air Force, 635 Danjae-ro, Namil-myeon, Cheongwon-gun, Chungcheongbuk-do 363-849, South Korea. apkimhs@gmail.com |
| Key Words |
Hepatic fibrosis; Cirrhosis; Hypoxia; Hyperoxia; Transforming growth factor-β |
| Core Tip |
We observed that both hypoxic and hyperoxic rat livers exhibited significantly higher frequencies of hepatic cirrhosis than untreated rat livers. We also observed that hepatic transforming growth factor-β (TGF-β) expression in hyperoxic rats was significant higher than that in untreated rats, suggesting that TGF-β is involved in the acceleration of hepatic fibrosis under hyperoxic conditions. To the best of our knowledge, up-regulated TGF-β expression in the livers of cirrhotic rats exposed to hyperoxia has not been reported. |
| Publish Date |
2014-03-18 14:14 |
| Citation |
Lee SH, Do SI, Kim HS. Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression. World J Gastroenterol 2014; 20(11): 3011-3017 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i11/3011.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i11.3011 |
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