Publication Name	World Journal of Gastroenterology
Manuscript ID	4488
Country	South Korea

Received	2013-07-02 09:46
Peer-Review Started	2013-07-02 15:45
To Make the First Decision	2013-10-29 12:45
Return for Revision	2013-11-04 15:57
Revised	2013-11-10 18:41
Second Decision	2014-01-06 17:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-06 19:11
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-02-17 17:48
Typeset the Manuscript	2014-03-04 11:03
Publish the Manuscript Online	2014-03-18 14:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Autobiography
Article Title	Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression
Manuscript Source	Invited Manuscript
All Author List	Sang Hwa Lee, Sung-Im Do and Hyun-Soo Kim
Funding Agency and Grant Number	Funding Agency Grant Number Aerospace Medicine Research Project funded by the Medical Division, Headquarter, Republic of Korea Air Force (2012)
Corresponding Author	Hyun-Soo Kim, MD, Department of Pathology, Aerospace Medicine Research Center, Aerospace Medical Center, Republic of Korea Air Force, 635 Danjae-ro, Namil-myeon, Cheongwon-gun, Chungcheongbuk-do 363-849, South Korea. apkimhs@gmail.com
Key Words	Hepatic fibrosis; Cirrhosis; Hypoxia; Hyperoxia; Transforming growth factor-β
Core Tip	We observed that both hypoxic and hyperoxic rat livers exhibited significantly higher frequencies of hepatic cirrhosis than untreated rat livers. We also observed that hepatic transforming growth factor-β (TGF-β) expression in hyperoxic rats was significant higher than that in untreated rats, suggesting that TGF-β is involved in the acceleration of hepatic fibrosis under hyperoxic conditions. To the best of our knowledge, up-regulated TGF-β expression in the livers of cirrhotic rats exposed to hyperoxia has not been reported.
Publish Date	2014-03-18 14:14
Citation	Lee SH, Do SI, Kim HS. Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression. World J Gastroenterol 2014; 20(11): 3011-3017
URL	http://www.wjgnet.com/1007-9327/full/v20/i11/3011.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i11.3011

Full Article (PDF)	WJG-20-3011.pdf
Full Article (Word)	WJG-20-3011.doc
Manuscript File	4488-Review.doc
Answering Reviewers	4488-Answering reviewers.pdf
Copyright License Agreement	4488-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	editing certificate.pdf
Peer-review Report	4488-Peer reviewer(s).pdf
Scientific Editor Work List	4488-Scientific editor work list.doc