Publication Name	World Journal of Gastroenterology
Manuscript ID	4488
Country	South Korea

Received	2013-07-02 09:46
Peer-Review Started	2013-07-02 15:45
First Decision by Editorial Office Director
Return for Revision	2013-11-04 15:57
Revised	2013-11-10 18:41
Publication Fee Transferred
Second Decision by Editor	2014-01-06 17:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-01-06 19:11
Articles in Press
Edit the Manuscript by Language Editor	2014-02-17 17:48
Typeset the Manuscript	2014-03-04 11:03
Publish the Manuscript Online	2014-03-18 14:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Autobiography
Article Title	Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression
Manuscript Source	Invited Manuscript
All Author List	Sang Hwa Lee, Sung-Im Do and Hyun-Soo Kim
Funding Agency and Grant Number	Funding Agency Grant Number Aerospace Medicine Research Project funded by the Medical Division, Headquarter, Republic of Korea Air Force (2012)
Corresponding Author	Hyun-Soo Kim, MD, Department of Pathology, Aerospace Medicine Research Center, Aerospace Medical Center, Republic of Korea Air Force, 635 Danjae-ro, Namil-myeon, Cheongwon-gun, Chungcheongbuk-do 363-849, South Korea. apkimhs@gmail.com
Key Words	Transforming growth factor-β; Hyperoxia; Hypoxia; Cirrhosis; Hepatic fibrosis
Core Tip	We observed that both hypoxic and hyperoxic rat livers exhibited significantly higher frequencies of hepatic cirrhosis than untreated rat livers. We also observed that hepatic transforming growth factor-β (TGF-β) expression in hyperoxic rats was significant higher than that in untreated rats, suggesting that TGF-β is involved in the acceleration of hepatic fibrosis under hyperoxic conditions. To the best of our knowledge, up-regulated TGF-β expression in the livers of cirrhotic rats exposed to hyperoxia has not been reported.
Publish Date	2014-03-18 14:14
Citation	Lee SH, Do SI, Kim HS. Hyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression. World J Gastroenterol 2014; 20(11): 3011-3017
URL	http://www.wjgnet.com/1007-9327/full/v20/i11/3011.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i11.3011

Full Article (PDF)	WJG-20-3011.pdf
Full Article (Word)	WJG-20-3011.doc
Manuscript File	4488-Review.doc
Answering Reviewers	4488-Answering reviewers.pdf
Copyright License Agreement	4488-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	editing certificate.pdf
Peer-review Report	4488-Peer reviewer(s).pdf
Scientific Editor Work List	4488-Scientific editor work list.doc