Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	44976
Country	Greece

Received	2018-12-05 02:12
Peer-Review Started	2018-12-05 09:41
To Make the First Decision	2019-01-22 02:36
Return for Revision	2019-01-27 01:43
Revised	2019-02-03 09:44
Second Decision	2019-02-18 08:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-02-19 15:22
Articles in Press	2019-02-19 15:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-03-14 06:42
Publish the Manuscript Online	2019-04-09 08:55

ISSN	2219-2808 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Pediatrics
Manuscript Type	Minireviews
Article Title	Applications of lung clearance index in monitoring children with cystic fibrosis
Manuscript Source	Unsolicited Manuscript
All Author List	Andrew Fretzayas, Konstantinos Douros, Maria Moustaki and Ioanna Loukou
ORCID	Author(s) ORCID Number Andrew Fretzayas http://orcid.org/0000-0003-0964-8594 Konstantinos Douros http://orcid.org/0000-0001-7632-1159 Maria Moustaki http://orcid.org/0000-0001-6818-4350 Ioanna Loukou http://orcid.org/0000-0002-3617-4526
Funding Agency and Grant Number
Corresponding Author	Andrew Fretzayas, MD, Department of Pediatrics, Athens Medical Center, Athens University Medical School, 5-7 Distomou str, Maroussi 15125, Greece. afretz@med.uoa.gr
Key Words	Cystic fibrosis; Respiratory health; Lung clearance index; Ventilation inhomogeneity
Core Tip	We herein present an overview of the applications of lung clearance index (LCI) in monitoring the respiratory health status of children with cystic fibrosis (CF). LCI is a more sensitive marker than spirometry and unlike spirometry it can be performed across the entire pediatric age range. At present, it is mostly used in research settings. However, as more data become available from longitudinal studies, it may be proved to be a very useful marker of respiratory status monitoring in children with CF, able to identify early those who are at risk for deterioration and allowing the early application of more aggressive interventions.
Publish Date	2019-04-09 08:55
Citation	Fretzayas A, Douros K, Moustaki M, Loukou I. Applications of lung clearance index in monitoring children with cystic fibrosis. World J Clin Pediatr 2019; 8(2): 15-22
URL	https://www.wjgnet.com/2219-2808/full/v8/i2/15.htm
DOI	https://dx.doi.org/10.5409/wjcp.v8.i2.15

Full Article (PDF)	WJCP-8-15.pdf
Full Article (Word)	WJCP-8-15.docx
Manuscript File	44976-Review.docx
Answering Reviewers	44976-Answering reviewers.pdf
Audio Core Tip	44976-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	44976-Conflict-of-interest statement.pdf
Copyright License Agreement	44976-Copyright license agreement.pdf
Peer-review Report	44976-Peer-review(s).pdf
Scientific Misconduct Check	44976-Scientific misconduct check.pdf
Scientific Editor Work List	44976-Scientific editor work list.pdf
CrossCheck Report	44976-CrossCheck report.pdf