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2/26/2019 11:29:05 AM | Browse: 896 | Download: 1575
Publication Name World Journal of Hepatology
Manuscript ID 45045
Country/Territory Brazil
Received
2018-12-08 11:11
Peer-Review Started
2018-12-10 07:55
To Make the First Decision
2019-01-07 00:45
Return for Revision
2019-01-11 08:29
Revised
2019-01-17 17:44
Second Decision
2019-01-26 10:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-26 23:21
Articles in Press
2019-01-26 23:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-02-24 06:14
Publish the Manuscript Online
2019-02-26 11:29
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Control Study
Article Title Comprehensive analysis of HFE gene in hereditary hemochromatosis and in diseases associated with acquired iron overload
Manuscript Source Unsolicited Manuscript
All Author List Wagner Narciso de Campos, Juliana Doblas Massaro, Eduardo Luiz Rachid Cançado, Cláudia Emília Vieira Wiezel, Aguinaldo Luiz Simões, Andreza Correa Teixeira, Fernanda Fernandes de Souza, Celso Teixeira Mendes-Junior, Ana de Lourdes Candolo Martinelli and Eduardo Antônio Donadi
ORCID
Author(s) ORCID Number
Wagner Narciso de Campos http://orcid.org/0000-0002-4118-2846
Juliana Doblas Massaro http://orcid.org/0000-0001-5324-5229
Eduardo Luiz Rachid Cançado http://orcid.org/0000-0002-9309-1524
Cláudia Emília Vieira Wiezel http://orcid.org/0000-0002-4381-0834
Aguinaldo Luiz Simões http://orcid.org/0000-0001-5950-894X
Andreza Correa Teixeira http://orcid.org/0000-0003- 4878-8215
Fernanda Fernandes de Souza http://orcid.org/0000-0002-2369-7686
Celso Teixeira Mendes-Junior http://orcid.org/0000-0002-7337-1203
Ana de Lourdes Candolo Martinelli http://orcid.org/0000-0002-1713-9039
Eduardo Antônio Donadi http://orcid.org/0000-0002-9457-9601
Funding Agency and Grant Number
Funding Agency Grant Number
"Conselho Nacional de Desenvolvimento Científico e Tecnológico” (CNPq, Brazil) 304931/2014-1
“Conselho Nacional de Desenvolvimento Científico e Tecnológico” (CNPq, Brazil) 148638/2010-4
Corresponding Author Eduardo Antônio Donadi, MD, PhD, Associate Professor, Division of Clinical Immunology, Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Monte Alegre, Ribeirão Preto 14048-900, Brazil. eadonadi@fmrp.usp.br
Key Words HFE gene; Hepatocellular carcinoma; Hepatitis C; Hemochromatosis hereditary; Alleles; Haplotypes
Core Tip Patients with hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) may or not develop iron overload (IO), which is associated with worset prognosis. The sequencing of the HFE gene permitted to assemble the previously described variation sites (H63DC>G-, S65CA>T and C282YG>A) associated with hereditary hemochromatosis into HFE haplotypes, under the standardized HLA nomenclature. A differential association of HFE alleles was observed for hereditary and acquired IO (HCV, HCC). In addition to the HFE gene, we also typed other major histocompatibility loci (HLA-A/-B/-C/ DRB1/-DQB1, and HLA-G 14bp INDEL and TNFa-d microsatellites) in the healthy population to understand how the HFE gene variability is associated with these loci.
Publish Date 2019-02-26 11:29
Citation Campos WN, Massaro JD, Cançado ELR, Wiezel CEV, Simões AL, Teixeira AC, Souza FF, Mendes-Junior CT, Martinelli ALC, Donadi EA. Comprehensive analysis of HFE gene in hereditary hemochromatosis and in diseases associated with acquired iron overload. World J Hepatol 2019; 11(2): 186-198
URL https://www.wjgnet.com/1948-5182/full/v11/i2/186.htm
DOI https://dx.doi.org/10.4254/wjh.v11.i2.186
Full Article (PDF) WJH-11-186.pdf
Full Article (Word) WJH-11-186.docx
STROBE Statement 45045-STROBE-Statement-revision.pdf
Manuscript File 45045-Review.docx
Answering Reviewers 45045-Answering reviewers.pdf
Audio Core Tip 45045-Audio core tip.mp3
Biostatistics Review Certificate 45045-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 45045-Conflict-of-interest statement.pdf
Copyright License Agreement 45045-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 45045-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 45045-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 45045-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 45045-Language certificate.pdf
Supplementary Material 45045-Supplementary material.pdf
Peer-review Report 45045-Peer-review(s).pdf
Scientific Misconduct Check 45045-Scientific misconduct check.pdf
Scientific Editor Work List 45045-Scientific editor work list.pdf