ISSN |
1948-5182 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Case Control Study |
Article Title |
Comprehensive analysis of HFE gene in hereditary hemochromatosis and in diseases associated with acquired iron overload
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Wagner Narciso de Campos, Juliana Doblas Massaro, Eduardo Luiz Rachid Cançado, Cláudia Emília Vieira Wiezel, Aguinaldo Luiz Simões, Andreza Correa Teixeira, Fernanda Fernandes de Souza, Celso Teixeira Mendes-Junior, Ana de Lourdes Candolo Martinelli and Eduardo Antônio Donadi |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
"Conselho Nacional de Desenvolvimento Científico e Tecnológico” (CNPq, Brazil) |
304931/2014-1 |
“Conselho Nacional de Desenvolvimento Científico e Tecnológico” (CNPq, Brazil) |
148638/2010-4 |
|
Corresponding Author |
Eduardo Antônio Donadi, MD, PhD, Associate Professor, Division of Clinical Immunology, Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Monte Alegre, Ribeirão Preto 14048-900, Brazil. eadonadi@fmrp.usp.br |
Key Words |
HFE gene; Hepatocellular carcinoma; Hepatitis C; Hemochromatosis hereditary; Alleles; Haplotypes |
Core Tip |
Patients with hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) may or not develop iron overload (IO), which is associated with worset prognosis. The sequencing of the HFE gene permitted to assemble the previously described variation sites (H63DC>G-, S65CA>T and C282YG>A) associated with hereditary hemochromatosis into HFE haplotypes, under the standardized HLA nomenclature. A differential association of HFE alleles was observed for hereditary and acquired IO (HCV, HCC). In addition to the HFE gene, we also typed other major histocompatibility loci (HLA-A/-B/-C/ DRB1/-DQB1, and HLA-G 14bp INDEL and TNFa-d microsatellites) in the healthy population to understand how the HFE gene variability is associated with these loci. |
Publish Date |
2019-02-26 11:29 |
Citation |
Campos WN, Massaro JD, Cançado ELR, Wiezel CEV, Simões AL, Teixeira AC, Souza FF, Mendes-Junior CT, Martinelli ALC, Donadi EA. Comprehensive analysis of HFE gene in hereditary hemochromatosis and in diseases associated with acquired iron overload. World J Hepatol 2019; 11(2): 186-198 |
URL |
https://www.wjgnet.com/1948-5182/full/v11/i2/186.htm |
DOI |
https://dx.doi.org/10.4254/wjh.v11.i2.186 |