BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/21/2019 8:40:16 AM | Browse: 751 | Download: 1717
Publication Name World Journal of Gastroenterology
Manuscript ID 45053
Country/Territory China
Received
2019-01-16 01:30
Peer-Review Started
2019-01-16 09:12
To Make the First Decision
2019-02-14 01:07
Return for Revision
2019-02-15 03:36
Revised
2019-09-10 03:07
Second Decision
2019-09-12 09:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-13 04:21
Articles in Press
2019-09-13 04:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-09-26 01:35
Typeset the Manuscript
2019-11-20 08:09
Publish the Manuscript Online
2019-11-21 08:40
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Ubiquitin-conjugating enzyme E2T knockdown suppresses the hepatocellular tumorigenesis via inducing cell cycle arrest and apoptosis
Manuscript Source Unsolicited Manuscript
All Author List Jian Guo, Mu Wang, Jun-Ping Wang and Chang-Xin Wu
ORCID
Author(s) ORCID Number
Jian Guo http://orcid.org/0000-0002-9028-9308
Mu Wang http://orcid.org/0000-0002-5526-8149
Jun-Ping Wang http://orcid.org/0000-0002-7517-9936
Chang-Xin Wu http://orcid.org/0000-0002-7416-1662
Funding Agency and Grant Number
Corresponding Author Chang-Xin Wu, PhD, Professor, Key Laboratory of Molecular Biology and Biochemistry of Ministry of Education, Shanxi University, Taiyuan 030006, Shanxi Province, China. cxw20@sxu.edu.cn
Key Words Hepatocellular carcinoma; Ubiquitin-conjugating enzyme E2T; Cell cycle; Apoptosis; Tumorigenesis;
Core Tip Ubiquitin-conjugating enzyme E2T (UBE2T) is a member of the ubiquitin‑proteasome family. Although it has been reported that UBE2T promotes the growth of hepatocellular carcinoma (HCC) cells, the role of UBE2T in the HCC cell cycle, apoptosis and tumorigenesis is unclear. UBE2T was highly expressed in HCC tissues, and its expression was correlated with the survival of HCC patients. Silencing of UBE2T reduced the viability and xenograft tumor growth of HCC cells. Additionally, cell cycle arrest and apoptosis were induced by UBE2T knockdown. Numerous genes were mediated by UBE2T silencing in HCC cells. Therefore, UBE2T is a novel diagnostic and therapeutic target for HCC.
Publish Date 2019-11-21 08:40
Citation Guo J, Wang M, Wang JP, Wu CX. Ubiquitin-conjugating enzyme E2T knockdown suppresses the hepatocellular tumorigenesis via inducing cell cycle arrest and apoptosis. World J Gastroenterol 2019; 25(43): 6386-6403
URL https://www.wjgnet.com/1007-9327/full/v25/i43/6386.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i43.6386
Full Article (PDF) WJG-25-6386.pdf
Full Article (Word) WJG-25-6386.docx
Manuscript File 45053-Review_Edited.docx
Answering Reviewers 45053-Answering reviewers.pdf
Audio Core Tip 45053-Audio core tip.mp3
Biostatistics Review Certificate 45053-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 45053-Conflict-of-interest statement.pdf
Copyright License Agreement 45053-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 45053-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 45053-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 45053-Language certificate.pdf
Peer-review Report 45053-Peer-review(s).pdf
Scientific Misconduct Check 45053-Google-Yan JP-1.jpg
Scientific Misconduct Check 45053-Scientific misconduct check.pdf
Scientific Editor Work List 45053-Scientific editor work list.pdf