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Articles Published Processes
11/21/2019 8:40:16 AM | Browse: 911 | Download: 2243
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Received |
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2019-01-16 01:30 |
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Peer-Review Started |
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2019-01-16 09:12 |
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To Make the First Decision |
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2019-02-14 01:07 |
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Return for Revision |
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2019-02-15 03:36 |
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Revised |
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2019-09-10 03:07 |
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Second Decision |
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2019-09-12 09:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-09-13 04:21 |
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Articles in Press |
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2019-09-13 04:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-09-26 01:35 |
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Typeset the Manuscript |
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2019-11-20 08:09 |
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Publish the Manuscript Online |
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2019-11-21 08:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Ubiquitin-conjugating enzyme E2T knockdown suppresses the hepatocellular tumorigenesis via inducing cell cycle arrest and apoptosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian Guo, Mu Wang, Jun-Ping Wang and Chang-Xin Wu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chang-Xin Wu, PhD, Professor, Key Laboratory of Molecular Biology and Biochemistry of Ministry of Education, Shanxi University, Taiyuan 030006, Shanxi Province, China. cxw20@sxu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Ubiquitin-conjugating enzyme E2T; Cell cycle; Apoptosis; Tumorigenesis; |
| Core Tip |
Ubiquitin-conjugating enzyme E2T (UBE2T) is a member of the ubiquitin‑proteasome family. Although it has been reported that UBE2T promotes the growth of hepatocellular carcinoma (HCC) cells, the role of UBE2T in the HCC cell cycle, apoptosis and tumorigenesis is unclear. UBE2T was highly expressed in HCC tissues, and its expression was correlated with the survival of HCC patients. Silencing of UBE2T reduced the viability and xenograft tumor growth of HCC cells. Additionally, cell cycle arrest and apoptosis were induced by UBE2T knockdown. Numerous genes were mediated by UBE2T silencing in HCC cells. Therefore, UBE2T is a novel diagnostic and therapeutic target for HCC. |
| Publish Date |
2019-11-21 08:40 |
| Citation |
Guo J, Wang M, Wang JP, Wu CX. Ubiquitin-conjugating enzyme E2T knockdown suppresses the hepatocellular tumorigenesis via inducing cell cycle arrest and apoptosis. World J Gastroenterol 2019; 25(43): 6386-6403 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i43/6386.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i43.6386 |
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