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Articles Published Processes
3/20/2019 5:32:10 AM | Browse: 1030 | Download: 1780
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Received |
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2018-12-15 07:46 |
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Peer-Review Started |
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2018-12-17 07:16 |
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To Make the First Decision |
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2019-01-07 01:48 |
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Return for Revision |
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2019-01-07 05:31 |
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Revised |
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2019-01-22 05:01 |
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Second Decision |
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2019-01-25 10:12 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-01-26 05:32 |
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Articles in Press |
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2019-01-26 05:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-03-19 06:51 |
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Publish the Manuscript Online |
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2019-03-20 05:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lung-Yi Mak, Wai-Pan To, Danny Ka-Ho Wong, James Fung, Fen Liu, Wai-Kay Seto, Ching-Lung Lai and Man-Fung Yuen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Man-Fung Yuen, DSc, FRCP (C), MBBS, MD, MRCP, PhD, Professor, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road 102, Hong Kong , China. mfyuen@hkucc.hku.hk |
| Key Words |
Hepatocellular carcinoma; Hepatitis B; Liver fibrosis; Mac-2 binding protein glycosylation isomer; Biomarker |
| Core Tip |
Serum Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel marker to assess severity of liver disease. The aim of this study was to assess its role in prediction of incident hepatocellular carcinoma (HCC) in patients with chronic hepatitis B who were prospectively followed-up for a median duration of 13.1 years. High serum M2BPGi increased HCC risk by 4-5 folds. If M2BPGi is below the threshold (0.68 cut-off index), there is > 99% chance that the patient will not develop liver cancer in the subsequent 15 years. |
| Publish Date |
2019-03-20 05:32 |
| Citation |
Mak LY, To WP, Wong DKH, Fung J, Liu F, Seto WK, Lai CL, Yuen MF. Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients. World J Gastroenterol 2019; 25(11): 1398-1408 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i11/1398.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i11.1398 |
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