Publication Name	World Journal of Stem Cells
Manuscript ID	45091
Country	United Kingdom

Received	2019-01-16 01:56
Peer-Review Started	2019-01-16 12:40
To Make the First Decision	2019-01-29 23:59
Return for Revision	2019-01-31 01:33
Revised	2019-02-22 13:29
Second Decision	2019-03-19 05:47
Accepted by Journal Editor-in-Chief	2019-03-20 13:31
Accepted by Executive Editor-in-Chief	2019-03-26 16:21
Articles in Press	2019-03-26 16:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-05-24 06:26
Publish the Manuscript Online	2019-05-25 09:31

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Review
Article Title	Modelling mitochondrial dysfunction in Alzheimer’s disease using human induced pluripotent stem cells
Manuscript Source	Unsolicited Manuscript
All Author List	Kate Elizabeth Hawkins and Michael Duchen
ORCID	Author(s) ORCID Number Kate Elizabeth Hawkins http://orcid.org/0000-0001-6666-4238 Michael Duchen http://orcid.org/0000-0003-2548-4294
Funding Agency and Grant Number
Corresponding Author	Kate Elizabeth Hawkins, PhD, Postdoc, Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom. kate.hawkins@merck.com
Key Words	Induced pluripotent stem cells; Alzheimer’s disease; Mitochondria
Core Tip	Alzheimer’s disease (AD) is a huge burden on the healthcare system and on society. At present, there are no therapeutic approaches that address the underlying causes of this devastating disease, largely because we lack understanding of the underlying molecular mechanisms. Induced pluripotent stem cells (iPSCs) from AD or Down syndrome patients can be used to elucidate these molecular mechanisms, therefore presenting a novel approach to this problem. In this review, we focus on the ability of iPSC models to gain insight into the mitochondrial dysfunction that occurs during AD and therefore identify novel drug targets.
Publish Date	2019-05-25 09:31
Citation	Hawkins KE, Duchen MR, Modelling mitochondrial dysfunction in Alzheimer’s disease using human induced pluripotent stem cells. World J Stem Cells 2019; 11(5): 236-253
URL	https://www.wjgnet.com/1948-0210/full/v11/i5/236.htm
DOI	https://dx.doi.org/10.4252/wjsc.v11.i5.236

Full Article (PDF)	WJSC-11-236.pdf
Full Article (Word)	WJSC-11-236.docx
Manuscript File	45091-Review.docx
Answering Reviewers	45091-Answering reviewers.pdf
Audio Core Tip	45091-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	45091-Conflict-of-interest statement.pdf
Copyright License Agreement	45091-Copyright license agreement.pdf
Peer-review Report	45091-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	45091-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	45091-Scientific misconduct check.pdf
Scientific Editor Work List	45091-Scientific editor work list.pdf
CrossCheck Report	45091-CrossCheck report.pdf