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3/7/2019 3:51:24 AM | Browse: 984 | Download: 1254
Publication Name World Journal of Gastroenterology
Manuscript ID 45118
Country Brazil
Received
2018-12-19 07:30
Peer-Review Started
2018-12-21 03:29
To Make the First Decision
2019-01-07 02:52
Return for Revision
2019-01-07 10:16
Revised
2019-01-28 17:47
Second Decision
2019-02-15 09:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-02-16 02:48
Articles in Press
2019-02-16 02:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-06 09:15
Publish the Manuscript Online
2019-03-07 03:51
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Systematic Reviews
Article Title Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review
Manuscript Source Unsolicited Manuscript
All Author List Adérson Omar Mourão Cintra Damião, Matheus Freitas Cardoso de Azevedo, Alexandre de Sousa Carlos, Marcela Yumi Wada, Taciana Valéria Marcolino Silva and Flávio de Castro Feitosa
ORCID
Author(s) ORCID Number
Adérson Omar Mourão Cintra Damião http://orcid.org/0000-0001-7584-7351
Matheus Freitas Cardoso de Azevedo http://orcid.org/0000-0001-5487-9418
Alexandre de Sousa Carlos http://orcid.org/0000-0001-6485-7968
Marcela Yumi Wada http://orcid.org/0000-0001-5584-4372
Taciana Valéria Marcolino Silva http://orcid.org/0000-0003-2578-4537
Flávio de Castro Feitosa http://orcid.org/0000-0002-1086-8749
Funding Agency and Grant Number
Corresponding Author Flávio de Castro Feitosa, MSc, PhD, Doctor, Department of Medical Affairs, Takeda Pharmaceuticals, Rua Estilo Barroco, 721, São Paulo 04709-011, Brazil. flavio.feitosa@takeda.com
Key Words Inflammatory bowel diseases; Steroids; Sulfasalazine; Mesalamine; Azathioprine; Methotrexate; Mycophenolic acid; Cyclosporine; Tacrolimus; 6-Mercaptopurine
Core Tip Despite the advent of biological drugs, conventional therapy continues to be used in moderate to severe inflammatory bowel disease (MS-IBD), especially in countries where biologics are not covered by insurance. In this systematic review, the effectiveness of conventional therapy for MS-IBD is assessed. There are few studies concerning objective outcomes, especially for remission maintenance, mucosal healing and fecal calprotectin. Additionally, studies are mainly of very low or low quality. As conventional therapy is usually the main therapy for MS-IBD and biologics are used in patients who fail to respond to conventional drugs, robust studies are required to further our understanding of the effectiveness of conventional therapy because it is prescribed to many IBD patients.
Publish Date 2019-03-07 03:51
Citation Damião AOMC, Azevedo MFC, Carlos AS, Wada MY, Silva TVM, Feitosa FC. Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review. World J Gastroenterol 2019; 25(9): 1142-1157
URL https://www.wjgnet.com/1007-9327/full/v25/i9/1142.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i9.1142
Full Article (PDF) WJG-25-1142.pdf
Full Article (Word) WJG-25-1142.docx
Manuscript File 45118-Review.docx
Answering Reviewers 45118-Answering reviewers.pdf
Audio Core Tip 45118-Audio core tip.mp3
Biostatistics Review Certificate 45118-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 45118-Conflict-of-interest statement.pdf
Copyright License Agreement 45118-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 45118-Language certificate.pdf
Peer-review Report 45118-Peer-review(s).pdf
Scientific Misconduct Check 45118-Scientific misconduct check.pdf
Scientific Editor Work List 45118-Scientific editor work list.pdf