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Articles Published Processes
3/7/2019 3:51:24 AM | Browse: 1144 | Download: 1624
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Received |
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2018-12-19 07:30 |
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Peer-Review Started |
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2018-12-21 03:29 |
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To Make the First Decision |
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2019-01-07 02:52 |
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Return for Revision |
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2019-01-07 10:16 |
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Revised |
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2019-01-28 17:47 |
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Second Decision |
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2019-02-15 09:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-02-16 02:48 |
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Articles in Press |
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2019-02-16 02:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-03-06 09:15 |
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Publish the Manuscript Online |
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2019-03-07 03:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Adérson Omar Mourão Cintra Damião, Matheus Freitas Cardoso de Azevedo, Alexandre de Sousa Carlos, Marcela Yumi Wada, Taciana Valéria Marcolino Silva and Flávio de Castro Feitosa |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Flávio de Castro Feitosa, MSc, PhD, Doctor, Doctor, Department of Medical Affairs, Takeda Pharmaceuticals, Rua Estilo Barroco, 721, São Paulo 04709-011, Brazil. flavio.feitosa@takeda.com |
| Key Words |
Inflammatory bowel diseases; Steroids; Sulfasalazine; Mesalamine; Azathioprine; Methotrexate; Mycophenolic acid; Cyclosporine; Tacrolimus; 6-Mercaptopurine |
| Core Tip |
Despite the advent of biological drugs, conventional therapy continues to be used in moderate to severe inflammatory bowel disease (MS-IBD), especially in countries where biologics are not covered by insurance. In this systematic review, the effectiveness of conventional therapy for MS-IBD is assessed. There are few studies concerning objective outcomes, especially for remission maintenance, mucosal healing and fecal calprotectin. Additionally, studies are mainly of very low or low quality. As conventional therapy is usually the main therapy for MS-IBD and biologics are used in patients who fail to respond to conventional drugs, robust studies are required to further our understanding of the effectiveness of conventional therapy because it is prescribed to many IBD patients. |
| Publish Date |
2019-03-07 03:51 |
| Citation |
Damião AOMC, Azevedo MFC, Carlos AS, Wada MY, Silva TVM, Feitosa FC. Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review. World J Gastroenterol 2019; 25(9): 1142-1157 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i9/1142.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i9.1142 |
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