Publication Name	World Journal of Gastroenterology
Manuscript ID	4517
Country	Italy

Received	2013-07-03 09:43
Peer-Review Started	2013-07-03 16:00
To Make the First Decision	2013-07-19 08:44
Return for Revision	2013-07-20 21:12
Revised	2013-08-08 23:59
Second Decision	2013-09-17 09:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-17 11:33
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-29 10:27
Publish the Manuscript Online	2013-11-18 10:59

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Review
Article Title	Multimodal treatment of hepatocellular carcinoma on cirrhosis: An update
Manuscript Source	Invited Manuscript
All Author List	Marco Vivarelli, Roberto Montalti and Andrea Risaliti
Funding Agency and Grant Number
Corresponding Author	Marco Vivarelli, MD, Hepatobiliary and Abdominal Transplantation Surgery, Department of Gastroenterology and Transplantation, Polytechnic University of Marche, A.O.U. "Ospedali Riuniti", Via Conca 71, 60129 Ancona, Italy. vivarelli63@libero.it
Key Words	Hepatocellular carcinoma; Multimodal treatment; Locoregional treatments; Molecular targeted therapies; Liver resection; Liver transplantation
Core Tip	Hepatocellular carcinoma (HCC) occurs frequently, and its association with cirrhosis makes treatment complex and challenging. The treatment of HCC must take into account the presence and stage of chronic liver disease with the aim of preserving hepatic function that is often already impaired. The different treatment options include surgical resection, transplantation, local ablation, chemoembolization, radioembolization and molecular targeted therapies. Downstaging and bridging are different strategies for the management of HCC patients who will undergo liver transplantation. The purpose of this review is to provide a comprehensive description of the current treatment options for patients with HCC.
Publish Date	2013-11-18 10:59
Citation	Vivarelli M, Montalti R, Risaliti A. Multimodal treatment of hepatocellular carcinoma on cirrhosis: An update. World J Gastroenterol 2013; 19(42): 7316-7326
URL	http://www.wjgnet.com/1007-9327/full/v19/i42/7316.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i42.7316

Full Article (PDF)	WJG-19-7316.pdf
Manuscript File	4517-Review.doc
Answering Reviewers	4517-Answering reviewers.pdf
Copyright License Agreement	4517-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4517-Language certificate.pdf
Peer-review Report	4517-Peer review.pdf
Scientific Editor Work List	4517-Scientific editor work list.doc